Burrowing and nest building behavior as indicators of well-being in mice
Burrowing and nest building behavior as indicators of well-being in mice
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DOI：
10.1016/j.jneumeth.2014.02.001
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发表时间：
2014-08-30
影响因子：
3
通讯作者：
Jirkof, Paulin
中科院分区：
文献类型：
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作者：
Jirkof, Paulin
对疼痛、苦恼和痛苦的评估，以及对减压策略效果的评估，在动物实验中是至关重要的，但在实验室小鼠中可能具有挑战性。在家里的笼子里观察筑巢和挖洞的表现，已被证明是评估脑损伤或功能障碍以及神经退行性疾病的有价值且易于使用的工具。这两种行为都被用作精神疾病模型的参数，或用于监测感染后的疾病行为。在更现实和临床相关的疾病临床前模型中已经提出了它们的使用，减少这些行为似乎特别有用，作为功能障碍的早期迹象和监测疾病进展。最后，疼痛和压力会减少这两种行为。因此，结合特定的疾病标志物，筑巢和挖洞性能的变化可能有助于提供小鼠状态的全局图像，从而有助于监测以确保动物实验的健康。(C) 2014 Elsevier B.V.版权所有
The assessment of pain, distress and suffering, as well as evaluation of the efficacy of stress-reduction strategies, is crucial in animal experimentation but can be challenging in laboratory mice. Nest building and burrowing performance, observed in the home cage, have proved to be valuable and easy-to-use tools to assess brain damage or malfunction as well as neurodegenerative diseases. Both behaviors are used as parameters in models of psychiatric disorders or to monitor sickness behavior following infection. Their use has been proposed in more realistic and clinically relevant preclinical models of disease, and reduction of these behaviors seems to be especially useful as an early sign of dysfunction and to monitor disease progression. Finally, both behaviors are reduced by pain and stress. Therefore, in combination with specific disease markers, changes in nest building and burrowing performance may help provide a global picture of a mouse's state, and thus aid monitoring to ensure well-being in animal experimentation. (C) 2014 Elsevier B.V. All rights reserved.