Incidental pancreatic cystic neoplasms in an asymptomatic healthy population of 21,745 individuals: Large-scale, single-center cohort study.
Incidental pancreatic cystic neoplasms in an asymptomatic healthy population of 21,745 individuals: Large-scale, single-center cohort study.
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DOI：
10.1097/md.0000000000005535
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发表时间：
2016-12
期刊：
影响因子：
1.6
通讯作者：
Kim SW
中科院分区：
文献类型：
--
作者：
Chang YR;Park JK;Jang JY;Kwon W;Yoon JH;Kim SW
虽然偶然胰腺囊性肿瘤被诊断的频率越来越高，很少有人知道胰腺囊肿在一般人群中的准确患病率。本研究的目的是评估胰腺囊性肿瘤在无症状健康成人中的粗患病率，并计算年龄和性别调整后的全国患病率。在2003年至2013年期间，在首尔国立大学医院医疗保健系统江南中心共招募了21,745名接受腹部计算机断层扫描（CT）作为健康筛查检查的无症状个体。2010年全国人口数据来自韩国国家统计局。在457例患者中发现了偶发性胰腺囊性肿瘤，平均年龄为58.7岁。肿瘤类型由2名独立指定的放射科医生进行审查，最终诊断如下：导管内乳头状粘液性肿瘤：376例（82%），浆液性囊性肿瘤：19例（4%），粘液性囊性肿瘤：7例（2%），不确定囊肿：55例（12%）。8例行手术治疗。粗患病率为2.1%，年龄和性别调整后的预期全国患病率为2.2%。患病率随年龄增长而增加。在这里，我们报告了第一个在健康人群中进行的大规模研究，以了解胰腺囊性肿瘤的患病率;年龄和性别调整后的患病率为2.2%，并随年龄增长而增加。关于偶发性胰腺肿瘤的临床意义的进一步调查是必要的。
Although incidental pancreatic cystic neoplasms are being diagnosed with increasing frequency, little is known about the accurate prevalence of pancreatic cysts in the general population. The aims of this study were to evaluate the crude prevalence rate of pancreatic cystic neoplasms in asymptomatic healthy adults, and calculate the age- and sex-adjusted nationwide prevalence rate. A total of 21,745 asymptomatic individuals who underwent abdominal computed tomography (CT) as a health screening examination were enrolled between 2003 and 2013 at the Seoul National University Hospital Healthcare System Gangnam Center. Nationwide population data of 2010 were collected from the National Statistical Office, Korea. Incidental pancreatic cystic neoplasms were found in 457 individuals whose mean age was 58.7 years. The types of neoplasms were reviewed by 2 separate designated radiologists and the final diagnosis was made as follows: intraductal papillary mucinous neoplasm: 376 (82%), serous cystic neoplasm: 19 (4%), mucinous cystic neoplasm: 7 (2%), and indeterminate cysts: 55 (12%). Eight cases underwent operation. The crude prevalence rate was 2.1% and the age- and sex-adjusted expected nationwide prevalence was 2.2%. The prevalence increased with age. Here, we reported the first large-scale study among the healthy population to find out the prevalence rate of pancreatic cystic neoplasms; the age- and sex-adjusted prevalence was 2.2%, and increased with age. Further investigations regarding the clinical implications of incidental pancreatic neoplasms are necessary.