Cellular trafficking in trypanosomatids: a new target for therapies?
Cellular trafficking in trypanosomatids: a new target for therapies?
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DOI：
10.1016/s0020-7519(01)00145-x
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发表时间：
2001-05-01
影响因子：
4
通讯作者：
Traub-Cseko, YM
中科院分区：
文献类型：
--
作者：
Costa-Pinto, D;Trindade, LS;Traub-Cseko, YM
Pathogenic trypanosomatids cause a plethora of diseases marked by the lack of efficient vaccines and therapies. As a consequence, studies are being conducted that are geared towards the understanding of basic mechanisms and various biological aspects of these parasites that might be used as targets for new developments in these areas. One such aspect is the understanding of specific cellular trafficking mechanisms that might be attacked with the intention of disease control. In this paper, we give an overview of our current knowledge of cellular targeting mechanisms in trypanosomatids, with special emphasis on our data related to lysosomal targeting of cysteine proteinases in Leishmania. (C) 2001 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.
