Fourth ventricular CART reduces food and water intake and produces a conditioned taste aversion in rats
Fourth ventricular CART reduces food and water intake and produces a conditioned taste aversion in rats
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DOI：
10.1037/0735-7044.116.5.918
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发表时间：
2002-10-01
影响因子：
1.9
通讯作者：
Moran, TH
中科院分区：
文献类型：
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作者：
Aja, S;Robinson, BM;Moran, TH
可卡因和安非他明调节的转录肽(CART)如果到达第四脑室(4V)，则会减少大鼠的流食摄入量。为了测试4V Cart对喂养的特异性，作者比较了它减少流质饮食和水摄入量的能力，并测试了条件性味觉厌恶(CTA)。CART减少了30分钟的两种水的摄入量，并确保在I-MUG的门槛。在随后的两瓶试验中，氯化锂(0.15M，20毫升/公斤ip)和4V购物车(I-MUG)与新型糖精溶液配对后，与生理盐水相比，降低了糖精偏好。因此，CART可以生产CTA。这些数据表明，4V Cart在摄食行为中的作用并不是营养素所特有的，并表明4V Cart在减少摄入量方面的作用可能次于产生厌恶状态。
Cocaine- and amphetamine-regulated transcript peptide (CART) reduces rats' intake of liquid diet if the peptide reaches the 4th ventricle (4V). To test for specificity of 4V CART effects on feeding, the authors compared its ability to reduce intakes of liquid diet and water and tested for conditioned taste aversion (CTA). CART reduced 30-min intakes of both water and Ensure at a threshold of I mug. Lithium chloride (0.15 M, 20 ml/kg ip) and 4V CART (I mug) paired with novel saccharin solution reduced saccharin preferences similarly in subsequent 2-bottle tests, compared with saline. Thus, CART can produce CTA. These data demonstrate that 4V CART's actions in ingestive behavior are not specific to nutrients and suggest that aspects of 4V CART's actions in reducing intake may be secondary to the production of an aversive state.