N-cadherin-mediated cell contact regulates ovarian surface epithelial cell survival.
N-cadherin-mediated cell contact regulates ovarian surface epithelial cell survival.
复制标题
N-钙粘蛋白介导的细胞接触调节卵巢表面上皮细胞的存活。
DOI：
10.1159/000014630
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Peluso,JJ
中科院分区：
文献类型：
--
作者：
Peluso,JJ
The present study shows that in cells derived from the rat ovarian surface epithelium (i.e. ROSE-179 cells) the adhesion protein, N-cadherin, binds to the receptor for fibroblast growth factor (FGF). This interaction likely accounts for the ability of the N-cadherin antibody to decrease the activation (i.e. tyrosine phosphorylation) of the FGF receptor and induce apoptosis. The loss of N-cadherin-mediated cell contact also results in the accumulation of β-catenin within the nucleus. Since β-catenin also functions as a transcription factor, nuclear β-catenin may promote mRNA synthesis that is required for ROSE-179 cells to undergo apoptosis in response to serum/calcium withdrawal. This hypothesis requires further testing and validation.
