A COLLABORATIVE CASE-CONTROL STUDY OF NUTRIENT INTAKE AND PANCREATIC-CANCER WITHIN THE SEARCH PROGRAM
A COLLABORATIVE CASE-CONTROL STUDY OF NUTRIENT INTAKE AND PANCREATIC-CANCER WITHIN THE SEARCH PROGRAM
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DOI：
10.1002/ijc.2910510306
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发表时间：
1992-05-28
影响因子：
6.4
通讯作者：
WALKER, AM
中科院分区：
文献类型：
--
作者：
HOWE, GR;GHADIRIAN, P;WALKER, AM
在5个具有中到高发病率和不同饮食习惯的人群中进行胰腺癌的病例对照研究，使用共同的方案和问卷。在阿德莱德（澳大利亚）、蒙特利尔和多伦多（加拿大）、乌得勒支（荷兰）和奥波莱（波兰）确定的总共802例病例和1669例对照中完成了全面的饮食史。碳水化合物和胆固醇的摄入量与此正相关，膳食纤维和维生素C的摄入量与此负相关。这些关系在5项研究中基本一致，并显示出统计学显著性和基本单调的剂量-反应关系。碳水化合物摄入量最高与最低五分位数的相对风险估计为2.57（95%置信区间1.64-4.03），胆固醇2.68（1.72-4.17），膳食纤维0.45（0.30-0.63）和维生素C 0.53（0.38-0.76）。这些关联的一致性、强度和特异性为以下假设提供了证据：这些饮食因素中的一些或全部可能改变胰腺癌的风险。
Case-control studies of pancreatic cancer were conducted in 5 populations with moderate to high rates and differing dietary practices, using a common protocol and questionnaire. Comprehensive diet histories were completed for a total of 802 cases and 1669 controls identified in Adelaide (Australia), Montreal and Toronto (Canada), Utrecht (The Netherlands) and Opole (Poland). Positive associations were observed with intake of carbohydrates and cholesterol, and inverse associations with dietary fiber and vitamin C. These relationships were generally consistent among the 5 studies, and showed statistically significant and generally monotonic dose-response relationships. The relative risks for highest vs. lowest quintile of intake were estimated for carbohydrates to be 2.57 (95% confidence interval 1.64-4.03), cholesterol 2.68 (1.72-4.17), dietary fiber 0.45 (0.30-0.63), and vitamin C 0.53 (0.38-0.76). The consistency, strength, and specificity of these associations provides evidence for the hypothesis that some or all of these dietary factors may alter the risk of pancreatic cancer.