Event-related fMRI of pain: entering a new era in imaging pain
Event-related fMRI of pain: entering a new era in imaging pain
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DOI：
10.1097/00001756-199809140-00018
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发表时间：
1998-09-14
期刊：
影响因子：
1.7
通讯作者：
Mikulis, DJ
中科院分区：
文献类型：
--
作者：
Davis, KD;Kwan, CL;Mikulis, DJ
以前的疼痛成像研究使用的是长期(长达1分钟)伤害性刺激的区块设计，这种刺激不能很好地耐受，并受时间相互作用的影响。我们描述了一种改编的事件相关功能磁共振成像来研究短时间刺激下的疼痛。在1.5T GE超声测速磁共振系统上，对正常志愿者手进行短暂(S 1~3次)伤害性热刺激时，丘脑、前扣带回、岛叶和第二躯体感觉皮质的螺旋序列图像。一种与MRI兼容的计算机化评级系统持续监测受试者的疼痛。在大脑皮质和丘脑可清晰地观察到短暂的疼痛相关活动，血流动力学延迟为3-6个S。这些结果表明，短暂刺激和在线疼痛评分相结合可以用功能磁共振成像研究疼痛。神经报告9：3019-3023(C)1998 Lippincott Williams&Wilkins.
PREVIOUS imaging studies of pain used a block design of prolonged (up to 1 min) noxious stimulation that are not well tolerated and subject to temporal interactions. We describe an adaptation of event-related fMRI to study pain with short duration stimuli. Functional images were acquired with a spiral sequence on a 1.5T GE echospeed MRI system of the thalamus, anterior cingulate, insula and second somatosensory cortex during brief (1-3 s) noxious thermal stimulation of the hand of normal volunteers. An MRI-compatible computerized rating system continuously monitored subjects' pain. Brief pain-related activations were clearly identified in the cortex and thalamus with a hemodynamic delay of 3-6 s. These findings demonstrate that brief stimuli combined with on-line pain ratings can be used to study pain with fMRI. NeuroReport 9: 3019-3023 (C) 1998 Lippincott Williams & Wilkins.