Association between the serotonin 1A receptor C(-1019)G polymorphism and major depressive disorder in the northern Han ethnic group in China.
Association between the serotonin 1A receptor C(-1019)G polymorphism and major depressive disorder in the northern Han ethnic group in China.
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DOI：
10.1097/00029330-200805020-00002
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发表时间：
2008-05
影响因子：
6.1
通讯作者：
Ying Wu;Yong Xu;Yan Sun;Yan-fang Wang;Xia Li;Xiao-e Lang;Wei-ping Wang;Kerang Zhang
中科院分区：
文献类型：
--
作者：
Ying Wu;Yong Xu;Yan Sun;Yan-fang Wang;Xia Li;Xiao-e Lang;Wei-ping Wang;Kerang Zhang
背景近年来研究表明，5-羟色胺1A受体（5-HTR 1A）C（-1019）G多态性可能与抑郁症的易感性有关。本研究旨在探讨5-HTR 1A C（-1019）G多态性与中国北方汉族人群MDD的相关性。方法采用聚合酶链反应（PCR）技术检测400例MDD患者和400例年龄、性别匹配的健康对照者5-HTR 1A基因C（-1019）G。统计分析C（-1019）G与MDD的相关性。结果MDD组与对照组的基因型分布（Chi（2）= 10.913，df = 2，P = 0.004）和等位基因频率（Chi（2）= 10.379，df = 1，P = 0.001）差异均有统计学意义。女性受试者的基因型分布和等位基因频率均存在显著性差异（基因型分布：Chi（2）= 15.406，df = 2，P = 0.000;等位基因频率：Chi（2）= 15.552，df = 1，P = 0.000）和晚发型受试者（基因型分布：Chi（2）= 7.771，df = 2，P = 0.021;等位基因频率：Chi（2）= 8.007，df = 1，P = 0.005）。结论5-HTR 1A C（-1019）G多态性可能与MDD相关，可能是女性和晚发性MDD的易感基因。
BACKGROUND Recent studies have suggested that susceptibility to major depressive disorder (MDD) might be related to the serotonin 1A receptor (5-HTR1A) C (-1019) G polymorphism. In this study, we aimed to assess the association between 5-HTR1A C (-1019) G polymorphism and MDD in the Northern Han ethnic group of China. METHODS The C (-1019) G of 5-HTR1A was detected with polymerase chain reaction (PCR) in 400 patients with MDD and 400 unrelated age- and sex-matched healthy control subjects. Association between the C (-1019) G and MDD was statistically analyzed. RESULTS There was a statistically significant difference between MDD patients and controls in both the genotype distribution (Chi(2) = 10.913, df = 2, P = 0.004) and the allele frequency (Chi(2) = 10.379, df = 1, P = 0.001), and a significant difference in the genotype distribution and the allele frequency was found both in the female subjects (Genotype distribution: Chi(2) = 15.406, df = 2, P = 0.000; allele frequency: Chi(2) = 15.552, df = 1, P = 0.000) and the late-onset subjects (Genotype distribution: Chi(2) = 7.771, df = 2, P = 0.021; allele frequency: Chi(2) = 8.007, df = 1, P = 0.005) in the two groups. CONCLUSION These results suggest that 5-HTR1A C (-1019) G polymorphism is probably associated with MDD and it is likely to be the susceptible gene locus for the female and late-onset MDD.