Hyperpolarization of 13C through order transfer from parahydrogen:: A new contrast agent for MFI
Hyperpolarization of 13C through order transfer from parahydrogen:: A new contrast agent for MFI
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DOI：
10.1016/j.mri.2004.11.031
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发表时间：
2005-02-01
影响因子：
2.5
通讯作者：
Karlsson, M
中科院分区：
文献类型：
--
作者：
Goldman, M;Johannesson, H;Karlsson, M
有机分子中质子对的有序性，由于仲氢的氢化作用，可以通过适当的场操作在很大程度上转移到附近的碳13自旋上。在简要介绍氢化过程和氢化装置后，我们描述了在较低磁场下，通过从初始场到零场的突然下降和随后的绝热重磁化，向C-13自旋进行有序转移的过程。给出了几种化合物在没有弛豫时的预期最终极化。最后，我们展示了一个例子，在动物体内观察到的MR图像作为这种新方法的对比度能力的说明。(c)2005年爱思唯尔公司All rights reserved.
The order within proton pairs in organic molecules, resulting from hydrogenation with parahydrogen, can be transferred in great part to nearby carbon 13 spins through adequate field manipulations. The molecules with hyperpolarized C-13 thus obtained can be used as new contrast agents of high efficiency in MRI.After a brief presentation of the hydrogenation process and apparatus, in relatively low magnetic field, we describe the procedure of order transfer to the C-13 spins through a sudden drop from the initial field to zero field followed by an adiabatic remagnetization. The expected final polarizations in the absence of relaxation are given for several compounds. Finally, we show an example of MR images observed in vivo on animals as an illustration of the contrast capacity of this new method. (c) 2005 Elsevier Inc. All rights reserved.