Development of white matter tracts between and within the dorsal and ventral streams
Development of white matter tracts between and within the dorsal and ventral streams
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DOI：
10.1007/s00429-021-02414-5
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发表时间：
2021-01
影响因子：
3.1
通讯作者：
S. Vinci-Booher;B. Caron;D. Bullock;K. James;F. Pestilli
中科院分区：
文献类型：
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作者：
S. Vinci-Booher;B. Caron;D. Bullock;K. James;F. Pestilli
腹侧和背侧视觉流之间的相互作用程度在多个科学领域已经讨论了几十年。最近，由于自动化和可重复性方法的进步，几个直接连接与背侧和腹侧流相关的皮质区域的白质束已成为可能进行研究。这组纤维束的发育轨迹，这里称为后垂直通路(PVP)，尚未被描述。我们提出了白质发育的输入驱动模型，并以PVP的发展为例为该模型提供了证据。我们使用可重复的云计算方法和来自成人和儿童(5-8岁)的扩散成像来比较PVP的发育与腹侧和背侧通路内的束的发育。PVP结构比背流结构更像成虫，而比腹流结构更不像成虫。此外，PVP的微结构更类似于腹侧的微结构，而不是背侧的微结构，并通过儿童在知觉任务中的表现来预测。总体而言，结果表明，PVP在背侧视流的发展中可能起到潜在的作用，这可能与其在学习过程中促进腹侧和背侧视流之间的相互作用有关。我们的结果与提出的模型一致，表明主要白质通路的微结构发展至少部分与视觉系统内感觉信息的传播有关。
The degree of interaction between the ventral and dorsal visual streams has been discussed in multiple scientific domains for decades. Recently, several white matter tracts that directly connect cortical regions associated with the dorsal and ventral streams have become possible to study due to advancements in automated and reproducible methods. The developmental trajectory of this set of tracts, here referred to as the posterior vertical pathway (PVP), has yet to be described. We propose an input-driven model of white matter development and provide evidence for the model by focusing on the development of the PVP. We used reproducible, cloud-computing methods and diffusion imaging from adults and children (ages 5–8 years) to compare PVP development to that of tracts within the ventral and dorsal pathways. PVP microstructure was more adult-like than dorsal stream microstructure, but less adult-like than ventral stream microstructure. Additionally, PVP microstructure was more similar to the microstructure of the ventral than the dorsal stream and was predicted by performance on a perceptual task in children. Overall, results suggest a potential role for the PVP in the development of the dorsal visual stream that may be related to its ability to facilitate interactions between ventral and dorsal streams during learning. Our results are consistent with the proposed model, suggesting that the microstructural development of major white matter pathways is related, at least in part, to the propagation of sensory information within the visual system.