Acupoint Selection Rule Mining of Premature Ovarian Failure Treatment with Acupuncture and Moxibustion Based on the Data Analysis of Clinical Literature
Acupoint Selection Rule Mining of Premature Ovarian Failure Treatment with Acupuncture and Moxibustion Based on the Data Analysis of Clinical Literature
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DOI：
10.1109/bibm.2018.8621095
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发表时间：
2018-12
期刊：
影响因子：
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通讯作者：
Xiaochun Han;Yanni Fan;Haijun Zhao;Shijun Wang;Sisheng Tian;Hongyuan Zhang;Zhe Yang;Ru Zhang;Jing Zhang;Wei Shi
中科院分区：
文献类型：
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作者：
Xiaochun Han;Yanni Fan;Haijun Zhao;Shijun Wang;Sisheng Tian;Hongyuan Zhang;Zhe Yang;Ru Zhang;Jing Zhang;Wei Shi
目的：卵巢早衰（POF）对育龄妇女的生育能力有很大的负面影响。尽管针灸已被认为是治疗POF的有效疗法，但不同学者在取穴和配伍方面存在较大差异。本研究旨在通过对相关临床研究的梳理和分析，完善针灸治疗POF治疗的选穴规则。技术或方法：POF的文献来源于PubMed、CNKI、Cqvip和万方数据库。然后利用TCMISS 2.0软件对腧穴组合规律及其相关性进行分析。之后分别采用GraphPad Prism 6.0、SPSS 22.0和HemI 1.0.3进行频数分析和变量聚类分析。结果：研究表明，关元（CV4）和三阴交（SP6）是针灸治疗POF的核心穴位，有3个关键穴位组合：关元（CV4）-中极（CV3）-子宫（位于下腹）组合；关元（CV4）-中极（CV3）-子宫组合（位于下腹）；肾俞（BL23）脾俞（BL20）-肝俞（BL18）组合位于腰背；三阴交（SP6）-足三里（ST36）-太溪（KI3）-太冲（LR3）的组合位于下肢。临床或生物学影响：本研究揭示针灸治疗POF具有调节任脉（CV）、调通脉（TV）、平衡阴阳、行经活血的特点，为今后腧穴组合模型的构建提供有益的参考和客观证据。
Objectives: Premature ovarian failure (POF) has great negative influence on the reproductive ability of childbearing-aged women. Though acupuncture and moxibustion has been regarded as an effective therapy in POF treatment, there is much difference in acupoint selection and combination from different scholars. This research aims to improve acupuncture and moxibustion therapy and mine acupoint selection rules in POF treatment by sorting out and analyzing related clinical studies. Technology or Method: The literature of POF was gathered from databases of PubMed, CNKI, Cqvip and Wanfang. Then acupoint combinaiotn pattern and their correlation were analyzed by the software of TCMISS 2.0. After that, frequency analysis and variable cluster analysis were done by GraphPad Prism 6.0, SPSS 22.0 and HemI 1.0.3 respectively. Results: Study showed that Guanyuan (CV4) and Sanyinjiao (SP6) were the core acupoints in POF treatment with acupuncture and moxibustion and there were three key acupoint combinations: the combination of Guanyuan (CV4)-Zhongji (CV3)-uterus located in the hypogastric region; the combination of shenshu (BL23)Pishu (BL20)-Ganshu (BL18) located in the waist and back; the combinaiton of Sanyinjiao (SP6)-Zusanli (ST36)-Taixi (KI3)-Taichong (LR3) located in lower limbs. Clinical or Biological Impact: This research reveals that POF treatment with acupuncture and moxibustion therapy is characterized by regulation of conception vessel (CV) and thoroughfare vessel (TV), balance of yin and yang, menstruation promotion and blood activation, thus offering helpful reference and objective evidence for future acupoint combination-model construction.