Excess weight risk factor for alcoholic liver disease
Excess weight risk factor for alcoholic liver disease
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DOI：
10.1002/hep.510250120
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发表时间：
1997-01-01
期刊：
影响因子：
13.5
通讯作者：
Chaput, JC
中科院分区：
文献类型：
--
作者：
Naveau, S;Giraud, V;Chaput, JC
尽管乙醇的肝毒性已被证实，但只有8％至20％的慢性酗酒者会发展为肝硬化，这项研究的目的是评估超重是否是酒精性肝病的危险因素，研究了1604名酗酒患者，根据肝脏活检，194名患者的肝脏正常； 402人有脂肪变性但没有纤维化； 281 例出现纤维化，伴或不伴脂肪变性； 119 例患有急性酒精性肝炎（AAH），但没有肝硬化； 232 表明有肝硬化，无 AAH； 179 名患者出现肝硬化并伴有 AAH。 197名患有临床明显肝硬化的患者，在该研究中，研究了五个变量作为危险因素：年龄、性别、过去5年的每日饮酒量、酗酒的总持续时间和超重倾向（体重指数[BMI]女性大于或等于25，男性大于或等于27），根据过去10年的最低体重计算BMI， 逐步logistic回归分析，年龄、超重至少10年、女性、酗酒总持续时间与肝硬化的存在独立相关。在第二个分析中，女性超重是AAH的两个独立危险因素。在第三次分析中，超重至少 10 年是脂肪变性的唯一独立危险因素。这些结果表明，体重超重至少 10 年是肝硬化、AAH 和脂肪变性的危险因素。我们的结果表明，酒精性肝病患者因超重而摄入乙醇可能会产生代谢影响。
Though the hepatotoxicity of ethanol has been established, only 8% to 20% of chronic alcoholics develop cirrhosis, The aim of this study was to assess whether being overweight is a risk factor for alcoholic liver disease, One thousand six hundred four alcoholic patients were studied, According to the liver biopsies, 194 patients had a normal liver; 402 had steatosis without fibrosis; 281 presented with fibrosis, with or without steatosis; 119 presented with acute alcoholic hepatitis (AAH) without cirrhosis; 232 indicated cirrhosis without AAH; and 179 presented with cirrhosis with AAH. One hundred ninety-seven patients had clinically obvious cirrhosis, In the study, five variables were studied as risk factors: age, sex, daily consumption of alcohol during the previous 5 years, the total duration of alcohol abuse, and tendency to be overweight (body mass index [BMI] greater than or equal to 25 in women and greater than or equal to 27 in men), The BMI was calculated according to the minimum weight over the 10 previous years, In the first stepwise logistic regression analysis, age, being overweight for at least 10 years, being of the female sex, and the total duration of alcohol abuse were independently correlated with the presence of cirrhosis, In the second analysis, female sex being overweight were the two independent risk factors of AAH. In the third analysis, being overweight for at least 10 years was the only independent risk factor of steatosis, These results show that the presence of excess weight for at least 10 years is a risk factor for cirrhosis, AAH, and steatosis, Our results suggest that there is a possible potential for the metabolic effects of ethanol ingestion caused by excess weight in patients with alcoholic liver disease.