Role of germinal centers in the generation of B cell memory.
Role of germinal centers in the generation of B cell memory.
复制标题
生发中心在 B 细胞记忆生成中的作用。
DOI：
10.1007/bf02923511
复制
发表时间：
1985
影响因子：
2.6
通讯作者：
Thorbecke,GJ
中科院分区：
文献类型：
--
作者：
Coico,RF;Thorbecke,GJ
In 1959 Jaroslav~ TERZL, as one of the first to realize the importance of studying cellular aspects of the immune response, organized the first of the renowned series of Czechoslovakian Immunology meetings. At that time we knew that lymphocytes and plasma cells both played a role in antibody formation, but the interrelationship between these two cell types did not become clear until 1969, around the time of the third and, unfortunately, last meeting. Insight into heterogeneity of immunoglobulins and the biological properties of different isotypes made rapid progress between the first and the second meeting (1964). Jaroslav STERZL made many important scientific contributions to our understanding of the ontogeny and kinetics of the immune response. In addition, by organizing these catalytic meetings in the field of cellular immunology, with their animated debates, one might say that he presided over the development of cellular immunology. It is, therefore, with pleasure and respect that we participate in this celebration of his sixtieth birthday.Our interest in germinal centers of lymphoid tissue was stimulated by findings reported by the late Bob White (White et al. 1960) at the first Prague meeting. Although for many years following this meeting we attempted to determine the relevance of germinal center cell proliferation to immunological memory, it was not until we could differentiate between T and B lymphocytes that a meaningful examination of this relationship could be made.
