Autobiographical Memory Fluency Reductions in Cognitively Unimpaired Middle-Aged and Older Adults at Increased Risk for Alzheimer's Disease Dementia.
Autobiographical Memory Fluency Reductions in Cognitively Unimpaired Middle-Aged and Older Adults at Increased Risk for Alzheimer's Disease Dementia.
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DOI：
10.1017/s1355617720001319
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发表时间：
2021-10
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影响因子：
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通讯作者：
Ryan L
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作者：
Grilli MD;Wank AA;Huentelman MJ;Ryan L
近期研究表明，患阿尔茨海默病（AD）痴呆风险较高但认知未受损的老年人，其神经心理学特征常常表现出细微的认知变化。新出现的证据显示，自传体记忆（即对个人事件和知识的记忆）可能对早期与AD相关的认知变化较为敏感。在本研究中，我们调查了自传体记忆类别范例的快速生成（这是一种对易受早期AD影响的神经网络造成负担的检索过程）在载脂蛋白E基因（APOE）e4等位基因的认知未受损的中老年携带者中是否受损，APOE4会增加患AD痴呆的风险。
除了标准的神经心理学测试外，我们对一组认知未受损的中老年成年人（n = 45，其中APOE4携带者n = 20）进行了一项流畅性任务，该任务要求为两种自传体记忆类型（即情景记忆和个人语义记忆）生成范例。
虽然在标准神经心理学测试中未发现APOE4携带者存在缺陷，但APOE4组的情景记忆和个人语义范例生成有所减少。
与AD高风险相关的自传体记忆异常在流畅性方面很明显，并影响情景记忆和个人语义记忆。
Recent research has revealed that cognitively unimpaired older adults who are at higher risk for developing Alzheimer’s disease (AD) dementia often exhibit subtle cognitive alterations in their neuropsychological profiles. Emerging evidence suggests that autobiographical memory, which is memory for personal events and knowledge, may be sensitive to early AD-related cognitive alterations. In the present study, we investigated whether the rapid generation of autobiographical memory category exemplars, a retrieval process that taxes the neural network that is vulnerable to early AD, is compromised in cognitively unimpaired middle-aged and older carriers of the e4 allele of the apolipoprotein E gene (APOE4), which increases risk for AD dementia. In addition to standard neuropsychological tests, we administered a fluency task that requires generating exemplars for two types of autobiographical memory, namely episodic memories and personal semantics, to a group of cognitively unimpaired middle-aged and older adults (n = 45) that was enriched with APOE4 carriers (n = 20). While no APOE4 deficits were found on standard neuropsychological tests, episodic and personal semantic exemplar generation was reduced in the APOE4 group. Autobiographical memory aberrations associated with higher risk for AD are evident in fluency and affect both episodic memory and personal semantics.