The Art of War: harnessing the epigenome against cancer.
The Art of War: harnessing the epigenome against cancer.
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DOI：
10.12688/f1000research.12833.1
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Dalal Y
中科院分区：
文献类型：
--
作者：
Nye J;Melters DP;Dalal Y
组蛋白伴侣是染色质结构和功能不可或缺的调节因子。最近的研究表明，它们在癌症中经常被错误调节，这可能对肿瘤生长和生存产生深远的影响。在这里，我们专注于基本H3组蛋白变体H3.3和CENP-A的分子伴侣，特别是HIRA，DAXX/ATRX，DEK和HJURP。本文综述了最近的研究阐明了它们在调节染色质中的作用，并讨论了如何利用癌症特异性染色质相互作用靶向癌细胞。
Histone chaperones are indispensable regulators of chromatin structure and function. Recent work has shown that they are frequently mis-regulated in cancer, which can have profound consequences on tumor growth and survival. Here, we focus on chaperones for the essential H3 histone variants H3.3 and CENP-A, specifically HIRA, DAXX/ATRX, DEK, and HJURP. This review summarizes recent studies elucidating their roles in regulating chromatin and discusses how cancer-specific chromatin interactions can be exploited to target cancer cells.