Seasonal trends of human parainfluenza viral infections: United States, 1990-2004
Seasonal trends of human parainfluenza viral infections: United States, 1990-2004
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DOI：
10.1086/507638
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发表时间：
2006-10-15
影响因子：
11.8
通讯作者：
Anderson, Larry J.
中科院分区：
文献类型：
--
作者：
Fry, Alicia M.;Curns, Aaron T.;Anderson, Larry J.
背景人副流感病毒（HPIV）是儿童和成人上、下呼吸道疾病的重要病因。我们描述的季节性趋势，个别HPIV血清型和呼吸道合胞病毒在美国使用的样本的百分比与阳性检测结果报告的国家呼吸道和肠道病毒监测系统在1990年至2004年期间的数据。使用早期像差报告系统的累积和方法C2，通过检测阳性HPIV检测结果数量显著大于前几周观察到的每种类型的时间段，确定活动峰值的开始和结束日期。在研究期间，每年4月至6月和11月至11月期间，HPIV-3和HPIV-2阳性检测结果的百分比分别增加。在奇数年的9月至12月期间，HPIV-1阳性检测结果的百分比每两年增加一次。在HPIV-1不循环的年份，报告了更多的HPIV-3活性，无论是作为一个较长的春季，还是作为第二个较小的活动增加期，在秋季注意到。呼吸道合胞病毒活动的季节性高峰出现在每年的11月至4月。我们提供了一个国家的HPIV活动在15年的研究期间，并证明了不同的季节性高峰活动HPIV-1，HPIV-2和HPIV-3。此外，我们的数据表明HPIV-3和HPIV-1活性之间存在相互作用，这可能对未来的预防策略产生影响。
Background. Human parainfluenza viruses (HPIVs) are important causes of upper and lower respiratory tract illness among children and adults.Methods. We describe seasonal trends for individual HPIV serotypes and respiratory syncytial virus in the United States using data on the percentage of specimens with positive test results reported to the National Respiratory and Enteric Viruses Surveillance System during the period 1990-2004. Onset and conclusion dates for peaks in activity were determined with the Early Aberration Reporting System's cumulative sum method C2 by detecting periods when the number of positive HPIV test results was significantly greater than that observed for preceding weeks for each serotype.Results. During the study period, increases in the percentage of positive HPIV-3 and HPIV-2 test results occurred annually during April-June and October-November, respectively. Increases in the percentage of positive HPIV-1 test results occurred biennially during September-December during odd-numbered years. During years when HPIV-1 was not circulating, more HPIV-3 activity was reported, either as a longer spring season or as a second smaller period of increased activity noted in the fall. Seasonal peaks in respiratory syncytial virus activity occurred annually during November-April.Conclusions. We provide a national perspective for HPIV activity during the 15-year study period and demonstrate distinct seasonal peaks in activity for HPIV-1, HPIV-2, and HPIV-3. In addition, our data suggest that there is an interaction between HPIV-3 and HPIV-1 activity, which may have implications in future prevention strategies.