Prenatal exposure to lead in relation to risk of preterm low birth weight: A matched case-control study in China.
Prenatal exposure to lead in relation to risk of preterm low birth weight: A matched case-control study in China.
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产前铅暴露与早产低出生体重风险的关系：中国的一项匹配病例对照研究
DOI：
10.1016/j.reprotox.2015.06.051
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发表时间：
2015-11
期刊：
影响因子：
--
通讯作者：
Xu S
中科院分区：
文献类型：
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作者：
Zhang B;Xia W;Li Y;Bassig BA;Zhou A;Wang Y;Li Z;Yao Y;Hu J;Du X;Zhou Y;Liu J;Xue W;Ma Y;Pan X;Peng Y;Zheng T;Xu S
我们调查了产前暴露于铅（Pb）和早产低出生体重（PLBW）的风险之间的关系。对408例（102例和306例对照）产妇出生时尿液中的铅浓度进行了分析和肌酐校正。PLBW组中位铅浓度（10.60 μg Pb/g肌酐）高于对照组（7.28 μg Pb/g肌酐）。当最高分位数与最低分位数的铅水平进行比较时，观察到PLBW的校正优势比（OR）为2.96 （95% CI = 1.49-5.87）。这种关联在女婴中更为明显（最高胎位校正OR = 3.67, 95% CI = 1.35-9.93），而在男婴中更为明显（最高胎位校正OR = 1.91, 95% CI = 0.74-4.95）。我们的研究表明，目前在中国，产前暴露于铅水平与PLBW的风险升高有关。
We investigated the association between prenatal exposure to lead (Pb) and the risk of preterm low birth weight (PLBW). Pb concentrations in maternal urine collected at birth from 408 subjects (102 cases and 306 matched controls) were analyzed and adjusted by creatinine. The median Pb concentration in the PLBW cases (10.60 μg Pb/g creatinine) was higher than that of the controls (7.28 μg Pb/g creatinine). An adjusted odds ratio (OR) of 2.96 (95% CI = 1.49-5.87) for PLBW was observed when the highest tertile was compared to the lowest tertile of Pb levels. The association was more pronounced among female infants (adjusted OR = 3.67 for the highest tertile; 95% CI = 1.35-9.93) than male infants (adjusted OR = 1.91 for the highest tertile; 95% CI = 0.74-4.95). Our study suggests that prenatal exposure to levels of Pb encountered today in China is associated with an elevated risk of PLBW.