HIV-Host Interactions: Implications for Vaccine Design.
HIV-Host Interactions: Implications for Vaccine Design.
复制标题
DOI：
10.1016/j.chom.2016.02.002
复制
发表时间：
2016-03-09
影响因子：
30.3
通讯作者：
McMichael AJ
中科院分区：
文献类型：
--
作者：
Haynes BF;Shaw GM;Korber B;Kelsoe G;Sodroski J;Hahn BH;Borrow P;McMichael AJ
研制有效的艾滋病疫苗是全球的优先事项。然而，人类免疫缺陷病毒1型（HIV-1）的极端多样性（这是其突变以逃避免疫应答的倾向的结果）以及阻止引发保护性免疫应答的宿主因素沿着，继续阻碍疫苗开发。对传播病毒的生物学、其包膜三聚体的结构和性质、灵长类动物中疫苗诱导的CD 8 T细胞控制以及广泛中和抗体激发的宿主控制的理解的突破性进展已经产生了新的疫苗策略。尽管有这样的希望，但来自临床前试验的新数据加强了对病毒宿主生物学的进一步了解的需要，以促进成功疫苗的开发。
Development of an effective AIDS vaccine is a global priority. However, the extreme diversity of human immunodeficiency virus type 1 (HIV-1), which is a consequence of its propensity to mutate to escape immune responses, along with host factors that prevent the elicitation of protective immune responses, continue to hinder vaccine development. Breakthroughs in understanding of the biology of the transmitted virus, the structure and nature of its envelope trimer, vaccine-induced CD8 T cell control in primates, and host control of broadly neutralizing antibody elicitation have given rise to new vaccine strategies. Despite this promise, emerging data from preclinical trials reinforce the need for gaining additional insight into virus – host biology in order to facilitate the development of a successful vaccine.