SERUM AMINO-ACID-CONCENTRATIONS IN 9 ATHLETES BEFORE AND AFTER THE 1993 COLMAR ULTRA TRIATHLON
SERUM AMINO-ACID-CONCENTRATIONS IN 9 ATHLETES BEFORE AND AFTER THE 1993 COLMAR ULTRA TRIATHLON
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DOI：
10.1055/s-2007-972984
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发表时间：
1995-04-01
影响因子：
2.5
通讯作者：
HAUSSINGER, D
中科院分区：
文献类型：
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作者：
LEHMANN, M;HUONKER, M;HAUSSINGER, D
氨基酸不平衡假说应解释疲劳起源于大脑在持续运动或过度训练作为支链（BCAA）/芳香族氨基酸（AAA）的不平衡增加脑色氨酸摄取和5-羟色胺合成。在完成1993年科尔马超级铁人三项之前和之后，在9名超级铁人三项运动员中测定血清氨基酸谱，以另外分析在持续超过23小时的这种极端长时间比赛期间这种氨基酸不平衡的程度。25种氨基酸的血清浓度总和从3962+/-846降至3255+/-694 umol，下降了18%。l（-1）可能反映了生物体的分解代谢状态，其中18种氨基酸减少9- 56%，胱氨酸（+38%）、甲硫氨酸（+24%）、酪氨酸（+10%）、苯丙氨酸（+12%）、游离色氨酸（+74%）增加，谷氨酰胺、亮氨酸和总色氨酸水平恒定。由于在超级铁人三项期间，运动员的血浆体积增加了约7.6%，体重减少了3.3 kg，因此假设细胞内水减少，细胞外液体增加。这种细胞水合状态的降低被视为蛋白质分解代谢信号。
The amino acid imbalance hypothesis should explain the fatigue originating in the brain during sustained exercise or overtraining as a branched-chain (BCAA)/aromatic amino acids (AAA) imbalance with increased brain tryptophan uptake and 5-hydroxytryptamine synthesis. The serum amino acid profile was determined in 9 ultra-triathletes before and after completing the 1993 Colmar ultra-triathlon to additionally analyse the extent of this amino acid imbalance during such an extreme prolonged contest lasting more than 23 hours. The summed serum concentration of 25 amino acids decreased by 18% from 3962+/-846 to 3255+/-694 umol . l(-1) likely reflecting a catabolic state of the organism with a decrease in 18 individual amino acids by 9-56%, an increase in cystine (+38%), methionine (+24%), tyrosine (+10%), phenylalanine (+12%), free tryptophan (+74%), and constant glutamine, leucine and total tryptophan levels. Since plasma Volume increased by approximately 7.6% with a 3.3 kg body mass decrease in the athletes during the ultra triathlon, a decrease in intra-cellular water with an extra-cellular fluid increase is hypothesized. This decrease in cellular hydration state is seen as a protein-catabolic signal.