Inhaled linalool-induced sedation in mice
Inhaled linalool-induced sedation in mice
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DOI：
10.1016/j.phymed.2008.08.001
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发表时间：
2009-04-01
期刊：
影响因子：
7.9
通讯作者：
Elisabetsky, Elaine
中科院分区：
文献类型：
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作者：
Linck, Viviane de Moura;da Silva, Adriana Lourenco;Elisabetsky, Elaine
芳樟醇是一种单萜，通常作为从芳香植物物种获得的精油的主要组分而被发现。其中许多在传统医疗系统中用作催眠镇静剂。芳樟醇的精神药理学评价（i.p.和i.c.v.）在各种小鼠模型中显示出显著的镇静和抗惊厥中枢作用。考虑到这一概况和吸入熏衣草精油的据称效果，本研究的目的是检查吸入芳樟醇对小鼠的镇静作用。将小鼠置于吸入室中60 min，吸入后立即评价动物的运动、巴比妥酸盐诱导的睡眠时间、体温和运动协调（旋转杆试验）。1%和3%芳樟醇使戊巴比妥钠睡眠时间延长（P < 0.01），使戊巴比妥钠睡眠时间缩短（P < 0.01）。
Linalool is a monoterpene often found as a major component of essential oils obtained from aromatic plant species., many of which are used in traditional medical systems as hypno-sedatives. Psychopharmacological evaluations of linalool (i.p. and i.c.v.) revealed marked sedative and anticonvulsant central effects in various mouse models. Considering this profile and alleged effects of inhaled lavender essential oil, the purpose of this study was to examine the sedative effects of inhaled linalool in mice. Mice were placed in an inhalation chamber during 60 min, in an atmosphere saturated with 1% or 3% linalool.Immediately after inhalation, animals were evaluated regarding locomotion, barbiturate-induced sleeping time, body temperature: and motor coordination (rota-rod test). The 1% and 3% linalool increased (p < 0.01) pentobarbital sleeping time and reduced (p