Finite element analysis of bone strength in osteogenesis imperfecta.
Finite element analysis of bone strength in osteogenesis imperfecta.
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DOI：
10.1016/j.bone.2020.115250
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发表时间：
2020-01
期刊：
影响因子：
4.1
通讯作者：
P. Varga;B. Willie;Chris Stephan;K. Kozloff;P. Zysset
中科院分区：
文献类型：
--
作者：
P. Varga;B. Willie;Chris Stephan;K. Kozloff;P. Zysset
作为一名专注的实验者，John Currey赞扬了有限元（FE）分析的巨大潜力，但也认识到其关键的局限性。根据他热情和丰富多彩的陈述，对FE方法在骨组织中的应用进行了回顾。在过去的几十年里，有限元分析大大有助于理解骨的层次组织中的结构-功能特性和模拟骨适应。骨折风险解剖部位骨强度FE分析的系统实验验证导致其在临床研究中的应用，以评估骨脆性抗吸收或合成代谢治疗的疗效。除了对健康或骨质疏松骨的成功分析外，FE分析越来越多地参与其他与脆性相关的骨疾病的研究。通过对成骨不全病例的介绍，总结了骨组织的多尺度改变及治疗效果。一些FE分析，试图回答开放性的问题，在OI然后报告。最后提出了一项原创研究，该研究使用microFE分析探索了接受硬化素中和抗体治疗的IV型OI Brtl/+小鼠模型的结构特性。在股骨的四点弯曲有限元模拟中使用相同的材料特性，不仅再现了实验值，而且还再现了检查疾病和治疗效果的统计比较。需要进一步的努力来建立在John Currey的非凡遗产的基础上，并澄清不同骨骼疾病对骨骼分级机械性能的影响。
As a dedicated experimentalist, John Currey praised the high potential of finite element (FE) analysis but also recognized its critical limitations. The application of the FE methodology to bone tissue is reviewed in the light of his enthusiastic and colorful statements. In the past decades, FE analysis contributed substantially to the understanding of structure-function properties in the hierarchical organization of bone and to the simulation of bone adaptation. The systematic experimental validation of FE analysis of bone strength in anatomical locations at risk of fracture led to its application in clinical studies to evaluate efficacy of antiresorptive or anabolic treatment of bone fragility. Beyond the successful analyses of healthy or osteoporotic bone, FE analysis becomes increasingly involved in the investigation of other fragility-related bone diseases. The case of osteogenesis imperfecta (OI) is exposed, the multiscale alterations of the bone tissue and the effect of treatment summarized. A few FE analyses attempting to answer open questions in OI are then reported. An original study is finally presented that explored the structural properties of the Brtl/+ murine model of OI type IV subjected to sclerostin neutralizing antibody treatment using microFE analysis. The use of identical material properties in the four-point bending FE simulations of the femora reproduced not only the experimental values but also the statistical comparisons examining the effect of disease and treatment. Further efforts are needed to build upon the extraordinary legacy of John Currey and clarify the impact of different bone diseases on the hierarchical mechanical properties of bone.