Insights into SARS-CoV-2 in Angola during the COVID-19 peak: Molecular epidemiology and genome surveillance.
Insights into SARS-CoV-2 in Angola during the COVID-19 peak: Molecular epidemiology and genome surveillance.
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DOI：
10.1111/irv.13198
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发表时间：
2023-09
影响因子：
4.4
通讯作者：
Morais, Joana
中科院分区：
文献类型：
--
作者：
Francisco, Ngiambudulu M.;van Wyk, Stephanie;Moir, Monika;San, James Emmanuel;Sebastiao, Cruz S.;Tegally, Houriiyah;Xavier, Joicymara;Maharaj, Akhil;Neto, Zoraima;Afonso, Pedro;Jandondo, Domingos;Paixao, Joana;Miranda, Julio;David, Kumbelembe;Ingles, Luzia;Pereira, Amilton;Paulo, Agostinho;Carralero, Raisa Rivas;Freitas, Helga Reis;Mufinda, Franco;Lutucuta, Silvia;Ghafari, Mahan;Giovanetti, Marta;Giandhari, Jennifer;Pillay, Sureshnee;Naidoo, Yeshnee;Singh, Lavanya;Tshiabuila, Derek;Martin, Darren Patrick;Chabuka, Lucious;Choga, Wonderful;Wanjohi, Dorcas;Mwangi, Sarah;Pillay, Yusasha;Kebede, Yenew;Shumba, Edwin;Ondoa, Pascale;Baxter, Cheryl;Wilkinson, Eduan;Tessema, Sofonias Kifle;Katzourakis, Aris;Lessells, Richard;de Oliveira, Tulio;Morais, Joana
在安哥拉，所有省份均报告了 COVID-19 病例，导致超过 105,000 例病例和超过 1900 人死亡。然而，安哥拉尚未对 SARS-CoV-2 病毒的引入和传播进行详细的基因组监测。我们的目的是调查安哥拉 COVID-19 大流行高峰期间的出现和流行病进展。我们生成了 1210 个全基因组 SARS-CoV-2 序列，将西非数据贡献给全球背景，并与全球毒株进行系统发育比较。使用祖先状态重建推断病毒运动事件。安哥拉的疫情以四波不同的感染为特征，主要由 12 个病毒谱系组成，包括 VOC、VOI 和 VUM C.16，这是西南非洲特有的病毒，并在该地区长期传播。安哥拉与其邻国之间发生了病毒交流，与巴西和葡萄牙的密切联系反映了这些国家之间的历史和文化联系。第一个病例可能来自南部非洲。缺乏强大的基因组监测网络和对国外测序的强烈依赖限制了实时数据生成以实现及时的疾病爆发应对，而这对于减轻安哥拉未来的疾病爆发仍然至关重要。
In Angola, COVID‐19 cases have been reported in all provinces, resulting in >105,000 cases and >1900 deaths. However, no detailed genomic surveillance into the introduction and spread of the SARS‐CoV‐2 virus has been conducted in Angola. We aimed to investigate the emergence and epidemic progression during the peak of the COVID‐19 pandemic in Angola. We generated 1210 whole‐genome SARS‐CoV‐2 sequences, contributing West African data to the global context, that were phylogenetically compared against global strains. Virus movement events were inferred using ancestral state reconstruction. The epidemic in Angola was marked by four distinct waves of infection, dominated by 12 virus lineages, including VOCs, VOIs, and the VUM C.16, which was unique to South‐Western Africa and circulated for an extended period within the region. Virus exchanges occurred between Angola and its neighboring countries, and strong links with Brazil and Portugal reflected the historical and cultural ties shared between these countries. The first case likely originated from southern Africa. A lack of a robust genome surveillance network and strong dependence on out‐of‐country sequencing limit real‐time data generation to achieve timely disease outbreak responses, which remains of the utmost importance to mitigate future disease outbreaks in Angola.
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影响因子：
5.3
作者：
Sagulenko P;Puller V;Neher RA
通讯作者：
Neher RA
影响因子：
5.8
作者：
Cleemput, Sara;Dumon, Wim;de Oliveira, Tulio
通讯作者：
de Oliveira, Tulio
DOI：
10.11604/pamj.2021.39.192.29491
发表时间：
2021
期刊：
The Pan African medical journal
影响因子：
--
作者：
Masresha B;Luce R;Katsande R;Dosseh A;Tanifum P;Lebo E;Byabamazima C;Kfutwah A
通讯作者：
Kfutwah A
影响因子：
10.7
作者：
Nguyen LT;Schmidt HA;von Haeseler A;Minh BQ
通讯作者：
Minh BQ
影响因子：
7.2
作者：
Gyeltshen D;Musa SS;Amesho JN;Ewelike SC;Bayoh AVS;Al-Sammour C;Camua AA;Lin X;Lowe M;Ahmadi A;Ntacyabukura B;Adebisi YA;Lucero-Prisno DE 3rd
通讯作者：
Lucero-Prisno DE 3rd