Evolution and Function of Thioester-Containing Proteins and the Complement System in the Innate Immune Response.
Evolution and Function of Thioester-Containing Proteins and the Complement System in the Innate Immune Response.
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DOI：
10.3389/fimmu.2017.00759
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发表时间：
2017
影响因子：
7.3
通讯作者：
Eleftherianos I
中科院分区：
文献类型：
--
作者：
Shokal U;Eleftherianos I
先天免疫反应在生物体中是进化保守的。补体系统是一种重要而有效的免疫防御机制。它由参与微生物检测的血浆蛋白组成，最终导致产生具有抗菌活性的各种分子。含硫酯蛋白（TEPs）是分泌性效应蛋白的超家族。在脊椎动物中，某些TEP通过促进免疫细胞的募集、吞噬作用和微生物入侵者的直接裂解而在先天免疫应答中起作用。昆虫是解剖先天免疫识别和对广泛的微生物感染的反应的分子基础的极好模型。令人印象深刻的进展，近年来产生了重要的信息TEPs的作用，在抗菌和抗寄生虫反应的听话的模式昆虫果蝇和蚊子疟疾载体冈比亚按蚊。这些知识对于更好地理解TEPs的进化及其参与宿主先天免疫系统的调节至关重要。
The innate immune response is evolutionary conserved among organisms. The complement system forms an important and efficient immune defense mechanism. It consists of plasma proteins that participate in microbial detection, which ultimately results in the production of various molecules with antimicrobial activity. Thioester-containing proteins (TEPs) are a superfamily of secreted effector proteins. In vertebrates, certain TEPs act in the innate immune response by promoting recruitment of immune cells, phagocytosis, and direct lysis of microbial invaders. Insects are excellent models for dissecting the molecular basis of innate immune recognition and response to a wide range of microbial infections. Impressive progress in recent years has generated crucial information on the role of TEPs in the antibacterial and antiparasite response of the tractable model insect Drosophila melanogaster and the mosquito malaria vector Anopheles gambiae. This knowledge is critical for better understanding the evolution of TEPs and their involvement in the regulation of the host innate immune system.