Heightening of the stress response during the first weeks after a mild traumatic brain injury.
Heightening of the stress response during the first weeks after a mild traumatic brain injury.
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DOI：
10.1016/j.neuroscience.2011.01.028
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发表时间：
2011-03-31
期刊：
影响因子：
3.3
通讯作者：
Taylor AN
中科院分区：
文献类型：
--
作者：
Griesbach GS;Hovda DA;Tio DL;Taylor AN
轻度创伤性脑损伤的影响范围从白色物质破坏到情感障碍。我们着手确定在轻度液压冲击损伤（FPI）（一种脑损伤的实验模型）后对限制诱导的应激的反应。下丘脑-垂体-肾上腺（HPA）轴调节皮质酮（CORT）和促肾上腺皮质激素（ACTH）的确定在第一个损伤后几周，这对应于同一时间段时，康复锻炼已被证明是无效的后，轻度FPI。成年雄性大鼠进行FPI或假损伤。其他大鼠仅暴露于麻醉。通过测量地塞米松（DEX）治疗对CORT和ACTH的影响来评估HPA调节。尾静脉血收集后30分钟的束缚应激，在伤后（PID）1，7和14天，前（0分钟）和30，60，90和120分钟后，应激发作。从这些研究的结果表明，应激反应是显着更明显的FPI后，皮质酮和促肾上腺皮质激素抑制诱导的增加更显着，更持久的控制相比。在所有组中观察到DEX对CORT和ACTH的抑制，表明轻度FPI后的应激高反应性并不归因于CORT反馈调节的敏感性降低。在轻度FPI后的前两周内，对应激事件的敏感性增加可能对早期康复治疗产生负面影响。
The effects of a mild traumatic brain injury range from white matter disruption to affective disorders. We set out to determine the response to restraint-induced stress after a mild fluid-percussion injury (FPI), an experimental model for brain injury. Hypothalamic-pituitary-adrenal (HPA) axis regulation of corticosterone (CORT) and adrenocorticotropic hormone (ACTH) was determined during the first post-injury weeks, which corresponds to the same time period when rehabilitative exercise has been shown to be ineffective after a mild FPI. Adult male rats underwent either a FPI or sham injury. Additional rats were only exposed to anesthesia. HPA regulation was evaluated by measuring the effects of dexamethasone (DEX) treatment on CORT and ACTH. Tail vein blood was collected following 30-min restraint stress, at post-injury days (PID) 1, 7 and 14, prior to (0 min) and at 30, 60, 90 and 120 min after stress onset. Results from these studies indicate that the stress response was significantly more pronounced after FPI in that CORT and ACTH restraint-induced increases were more pronounced and longer lasting compared to controls. DEX suppression of CORT and ACTH was observed in all groups, suggesting that stress hyper-responsiveness after mild FPI is not attributable to reduced sensitivity of CORT feedback regulation. The increased sensitivity to stressful events in the first two post-injury weeks after a mild FPI may have a negative impact on early rehabilitative therapies.
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影响因子：
4.2
作者：
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