Beyond Membranes: The Evolution of Plant Lipid Signaling
Beyond Membranes: The Evolution of Plant Lipid Signaling
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超越膜：植物脂质信号的演变
DOI：
10.1016/j.molp.2020.06.004
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发表时间：
2020
期刊：
影响因子：
27.5
通讯作者：
Hoffmann-Benning, Susanne
中科院分区：
文献类型：
--
作者：
Hoffmann-Benning, Susanne
脂质在植物中具有许多重要功能：它们是膜成分，因此在细胞分隔、膜曲率和脂筏/微域的形成中发挥重要作用；它们参与囊泡的形成和运输，并充当分子不受限制运输的屏障。脂质也是次生代谢物和储存化合物生物合成的重要中间体。更有趣的是它们在信号传递中的作用。传统上，人们认为植物信号脂质通过将信号复合物一部分的蛋白质募集或束缚到膜上来发挥作用，从而使它们接近受体等，或者通过将它们从信号级联中去除。其他的则负责调节囊泡出芽和融合，间接影响信号传导。问题出现了：所有这些信号脂质都与膜结合吗？近几个月来，研究人员在了解脂质在膜边界之外的作用方面取得了巨大进展。
Lipids have many essential functions in plants: They are membrane components and as such play an important role in compartmentation of the cell, membrane curvature, and formation of lipid rafts/microdomains; they participate in vesicle formation and trafficking, and act as a barrier to unrestricted trafficking of molecules. Lipids are also important intermediates in the biosynthesis of secondary metabolites and storage compounds. Even more interesting is their role in signaling. Traditionally, it was assumed that plant signaling lipids function by recruiting or tethering proteins that are part of signaling complexes to the membrane, thus either bringing them into the proximity of, for example, receptors, or by removing them from the signaling cascade. Others act in regulating vesicle budding and fusion, impacting signaling indirectly. The question arises: Are all these signaling lipids membrane bound? In recent months, researchers have made great progress in understanding the role of lipids beyond membrane boundaries.