Estimates of chronic hepatitis B virus infection in the Northern Territory.
Estimates of chronic hepatitis B virus infection in the Northern Territory.
复制标题
北领地慢性乙型肝炎病毒感染估计。
DOI：
--
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
P. McIntyre
中科院分区：
文献类型：
--
作者：
N. Wood;J. Backhouse;H. Gidding;G. Gilbert;G. Lum;P. McIntyre
（30.1-51.2%）， HBcAb 28% (16.4-39.3%), HBsAg 0.8%（0-1.7%）。这是自1990年在北领地实行乙肝病毒普遍免疫接种以来对乙肝病毒流行率的首次估计。与全国血清调查相比，1 - 4岁儿童HBsAb患病率显著（0.005）高（表2）反映了北领地免疫计划的影响（在收集了这些血清后，于2000年开始实施了一项全国婴儿计划）。北领地慢性乙肝病毒感染率估计为0.8%，与全国血清调查结果相似。虽然收集血清的受试者的状况尚不清楚，但估计约有50%将是土著人（个人通信，Gary Lum博士，北领地政府病理服务处主任）。与全国血清调查相比，所有年龄段有既往感染证据（HBcAb阳性）的比例更高（表2）。这在9岁以下儿童中尤为明显，北领地的这一比例是全国的15倍以上，尽管目前的疫苗接种方案可以预防这一年龄组的乙型肝炎感染。虽然检测的血清数量很少，而且没有个人临床数据，但在北领地土著儿童（包括来自偏远地区的儿童）的随机样本中，患病率可能更高。需要进行更具体的研究，以更详细地检查北领地乙型肝炎免疫方案的影响。
(30.1–51.2%), HBcAb 28 per cent (16.4–39.3%), and HBsAg 0.8 per cent (0–1.7%). These are the fi rst estimates of HBV prevalence since the introduction of universal HBV immunisation in the Northern Territory in 1990. The signifi cantly (0.005) higher prevalence of HBsAb in 1–4-year-olds, compared with the national serosurvey (Table 2) refl ects the impact of the Northern Territory immunisation program (a national infant program commenced in 2000, after these sera were collected). The estimated rate of chronic HBV infection in the Northern Territory (0.8%) was similar to that in the national serosurvey. Although the status of subjects whose sera were collected is not known, it was estimated that approximately 50 per cent would be Indigenous people (personal communication, Dr Gary Lum, Director, Northern Territory Government Pathology Service). Compared with the national serosurvey, there was a higher proportion with evidence of past infection (HBcAb positive) at all ages (Table 2). This was particularly noticeable for children aged under nine years, in whom the proportions were more than 15 times higher in the Northern Territory than nationally, even though hepatitis B infections in this age group are preventable by current vaccination programs. Although the number of sera tested was small and individual clinical data are not available, the prevalence in a random sample of Northern Territory Indigenous children, including those from remote regions, would be likely to be higher. More specifi c studies are needed to examine the impact of the hepatitis B immunisation program in the Northern Territory in more detail.