Wheezing is common in children with sickle cell disease when compared with controls.
Wheezing is common in children with sickle cell disease when compared with controls.
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与对照组相比，在患有镰状细胞疾病的儿童中喘息很常见。
DOI：
10.1097/mph.0000000000000239
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
DeBaun MR
中科院分区：
文献类型：
--
作者：
Galadanci NA;Liang WH;Galadanci AA;Aliyu MH;Jibir BW;Karaye IM;Inusa BP;Vermund SH;Strunk RC;DeBaun MR
在患有镰状细胞病(SCD)的儿童中，在没有哮喘的情况下可能会发生喘息。然而，在相同的环境下，患有SCD的儿童与没有SCD的儿童(对照组)相比，喘息的发生率是未知的。使用病例对照研究设计，我们检验了患有SCD的儿童比没有SCD的儿童有更高的喘息率的假设。我们从尼日利亚的一家社区医院招募了163名患有SCD的儿童(病例)和96名非SCD的儿童(对照)。家长的呼吸道症状报告是根据对美国胸科学会肺部疾病分会问卷问题的回答来确定的。SCD儿童的中位年龄为8.5岁，对照组为7.7岁。与对照组相比，患感冒时发生喘息(17.3%vs.2.1%，P<；0.01)和未患感冒时(4.9%vs.0%，P=0.03)的患者更容易发生喘息。病例发生喘息的几率是对照组的9.8倍(95%CI=2.3，42.2)。在多变量模型中，与喘息相关的唯一变量是SCD状态(优势比=18.7，95%可信区间2.5-142；P=0.005)。与同龄的非SCD儿童相比，SCD儿童的喘息率明显更高。
In children with sickle cell disease (SCD), wheezing may occur in the absence of asthma. However, the prevalence of wheezing in children with SCD when compared to children without SCD (controls) in the same setting is unknown. Using a case-control study design, we tested the hypothesis that children with SCD would have a higher rate of wheezing than those without SCD. We enrolled 163 children with SCD (cases) and 96 children without SCD (controls) from a community hospital in Nigeria. Parent reports of respiratory symptoms were identified based on responses to questions taken from the American Thoracic Society Division of Lung Diseases’ questionnaire. The median age was 8.5 years for children with SCD and 7.7 years for controls. Cases were more likely than controls to report wheezing both with colds (17.3% vs. 2.1%, P<0.01) and without colds (4.9% vs. 0%, P=0.03). Cases had 9.8 times greater odds of wheezing (95% CI=2.3, 42.2). In the multivariable model, the only variable associated with wheezing was SCD status (odds ratio =18.7, 95% confidence interval 2.5-142; P=0.005,). Children with SCD experience a significantly higher rate of wheezing when compared to similar aged children without SCD.