The population structure of Staphylococcus aureus among general practice patients from The Netherlands
The population structure of Staphylococcus aureus among general practice patients from The Netherlands
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DOI：
10.1111/j.1469-0691.2008.02662.x
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发表时间：
2009-02-01
影响因子：
14.2
通讯作者：
Stobberingh, E. E.
中科院分区：
文献类型：
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作者：
Donker, G. A.;Deurenberg, R. H.;Stobberingh, E. E.
目的了解金黄色葡萄球菌、葡萄球菌的流行情况、耐药谱及菌群结构。分析了从全科医生（GP）患者前鼻孔分离的金黄色葡萄球菌。对S.金黄色葡萄球菌的种群结构是必不可少的，作为鼻携带者的S.金黄色葡萄球菌感染的风险增加。金黄色葡萄球菌感染。S.金黄色葡萄球菌是从来自2691名患者的鼻拭子中分离的，这些患者在荷兰的29个GP实践中收集，没有感染的迹象。确定了几类抗生素的敏感性模式，以及S。金黄色葡萄球菌遗传背景，使用SPA分型。S.从2691个鼻拭子中的617个（23%）分离出金黄色葡萄球菌。对环丙沙星、复方新诺明、夫西地酸、大环内酯类和莫匹罗星的耐药率分别为0.2%、0%、6%、5%和1%。半数分离株与主要耐甲氧西林沙门氏菌的遗传背景相关。金黄色葡萄球菌（MRSA）克隆，例如克隆复合物（CC）1、CC 5、CC 8、CC 22、CC 30和CC 45，其余主要与CC 7、CC 12、CC 15、CC 26、CC 51和CC 101相关。抗性的低发生率表明，在荷兰的情况下，S。从就诊于非感染性疾病的患者中分离出的金黄色葡萄球菌并不代表抗生素耐药基因的大量储存。虽然没有发现MRSA分离株，但一些S.金黄色葡萄球菌分离株通常在社区相关（CA）-MRSA克隆（CC 1、CC 8和CC 30）中观察到，这可能表明这些分离株具有成为CA-MRSA的潜力。
To investigate the prevalence, the antibiotic resistance pattern and the population structure of Staphylococcus aureus, S. aureus isolates from the anterior nostrils of patients of general practitioners (GPs) were analysed. Insight into the S. aureus population structure is essential, as nasal carriers of S. aureus are at increased risk of developing an S. aureus infection. S. aureus was isolated from nasal swabs from 2691 patients with no sign of an infection collected in 29 GP practices in The Netherlands. The susceptibility pattern for several classes of antibiotics was determined, as well as the S. aureus genetic background, using spa typing. S. aureus was isolated from 617 of the 2691 (23%) nasal swabs. The prevalences of resistance to ciprofloxacin, co-trimoxazole, fusidic acid, macrolides and mupirocin were 0.2%, 0%, 6%, 5% and 1%, respectively. Half of the isolates were associated with a genetic background common to the major methicillin-resistant S. aureus (MRSA) clones, e.g. clonal complex (CC)1, CC5, CC8, CC22, CC30 and CC45, and the remainder were mainly associated with CC7, CC12, CC15, CC26, CC51 and CC101. The low prevalences of resistance suggest that, in the Dutch situation, S. aureus isolates from patients visiting their GP because of complaints not related to infection do not represent a large reservoir of antibiotic resistance genes. Although no MRSA isolates were found, the genetic background of some of the S. aureus isolates is commonly observed among community-associated (CA)-MRSA clones (CC1, CC8 and CC30), and this might suggest that these isolates have the potential to become CA-MRSA.