Human cytotrophoblast invasion.
Human cytotrophoblast invasion.
复制标题
DOI：
10.1006/scel.1993.1022
复制
发表时间：
1993-06-01
期刊：
影响因子：
--
通讯作者：
Damsky, C H
中科院分区：
文献类型：
--
作者：
Fisher, S J;Damsky, C H
在妊娠早期，胎儿绒毛膜绒毛与子宫壁接触，产生单核细胞滋养层柱，穿透子宫表面。从这些柱状细胞中发出细胞滋养层，侵入子宫及其小动脉深处。为了研究这种不寻常的、受调控的侵袭行为的分子基础，我们采用了多种方法的组合，包括细胞滋养层侵袭的体外模型和含有侵袭细胞滋养层的子宫活检切片的免疫细胞化学。我们的研究结果表明有趣的作用：基质降解金属蛋白酶，粘附受体及其细胞外基质配体，和I类分子HLA-G。
During early pregnancy, fetal chorionic villi that contact the uterine wall give rise to columns of mononuclear cytotrophoblasts that penetrate the superficial portion of the uterus. From these columns emanate cytotrophoblasts that invade deeply into the uterus and its arterioles. To investigate the molecular basis of this unusual, regulated invasive behavior, we used a combination of approaches that included an in vitro model of cytotrophoblast invasion and immunocytochemistry on uterine biopsy sections containing invading cytotrophoblasts. Our results showed interesting roles for: matrix-degrading metalloproteinases, adhesion receptors and their extracellular matrix ligands, and the class I molecule HLA-G.