HOXs and lincRNAs: Two sides of the same coin.
HOXs and lincRNAs: Two sides of the same coin.
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DOI：
10.1126/sciadv.1501402
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发表时间：
2016-01
期刊：
影响因子：
13.6
通讯作者：
Krumlauf R
中科院分区：
文献类型：
--
作者：
De Kumar B;Krumlauf R
Hox复合物：编码和非编码转录物之间动态相互作用的领域。成簇的Hox基因在调节动物发育中的轴向模式和制定基本的身体计划中起着重要作用。Hox集群的组织和监管格局中存在与其高度保守的功能角色相关的共同特征。嵌入脊椎动物Hox基因簇中的转录非编码序列的存在为深入了解与Hox基因相关的新的调控信息层提供了帮助。
The Hox complexes: Domains of dynamic interplay between coding and noncoding transcripts. The clustered Hox genes play fundamental roles in regulation of axial patterning and elaboration of the basic body plan in animal development. There are common features in the organization and regulatory landscape of Hox clusters associated with their highly conserved functional roles. The presence of transcribed noncoding sequences embedded within the vertebrate Hox clusters is providing insight into a new layer of regulatory information associated with Hox genes.