THE NITRIC OXIDE-SCAVENGING PROPERTIES OF GINKGO-BILOBA EXTRACT EGB-761
THE NITRIC OXIDE-SCAVENGING PROPERTIES OF GINKGO-BILOBA EXTRACT EGB-761
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DOI：
10.1006/bbrc.1994.1764
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发表时间：
1994-06-15
影响因子：
3.1
通讯作者：
PACKER, L
中科院分区：
文献类型：
--
作者：
MARCOCCI, L;MAGUIRE, JJ;PACKER, L
银杏叶提取物银杏叶提取物EGB 761在生理条件下，在体外无细胞系统中具有清除一氧化氮的作用。EGb 761与氧合血红蛋白竞争与过氧化氢酶复合体I相互作用时产生的一氧化氮反应。在氧与硝普钠产生的一氧化氮的反应中，也观察到了EGb761剂量依赖性的减少。这些数据表明，它可能是一氧化氮产生改变的潜在治疗条件。(C)1994年学术出版社。
Ginkgo biloba extract EGb 761 was found to be a scavenger of nitric oxide in in vitro acellular systems, under physiological conditions. EGb 761 competed with oxyhemoglobin for reaction with nitric oxide generated during the interaction Complex I of catalase. An EGb 761 dose-dependent decrease formed in the reaction of oxygen with nitric oxide produced from nitroprusside was also observed. These data implicate it as a potential therapeutic conditions of altered production of nitric oxide. (C) 1994 Academic Press, Inc.