Developmental improvements in voluntary control of behavior: Effect of preparation in the fronto-parietal network?
Developmental improvements in voluntary control of behavior: Effect of preparation in the fronto-parietal network?
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DOI：
10.1016/j.neuroimage.2014.03.008
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发表时间：
2014-09-01
期刊：
影响因子：
5.7
通讯作者：
Munoz, Douglas P.
中科院分区：
文献类型：
--
作者：
Alahyane, Nadia;Brien, Donald C.;Munoz, Douglas P.
为行动做准备的能力提高了行动的速度和准确性。虽然许多研究表明，行为表现在整个童年和青春期持续改善，但仍不清楚准备过程是否或如何随着发展而变化。在这里，我们使用了一个快速的事件相关的fMRI设计在三个年龄组（8-12，13-17，18-25岁），他们被指示执行一个prosaccade（看向周边目标）或一个antisaccade（看远离目标）的任务。我们比较了大脑活动的核心额顶叶网络内的眼跳控制在两个时代的眼跳生成：眼跳准备相关的任务指令与眼跳执行相关的目标外观。包括捕捉试验只包含任务指令，没有目标或眼跳反应，使我们能够隔离眼跳准备眼跳执行。五个感兴趣的区域被选中：额叶，补充，顶叶的眼睛领域，这是一贯的招聘过程中扫视一代，和两个地区参与自上而下的执行控制：背外侧前额叶和前扣带皮层。我们的研究结果表明，眼跳表现的发展改善与更好的眼跳准备，而不是眼跳执行。这些发展差异主要归因于儿童谁表现出减少额顶叶活动在前扫视和反扫视准备，沿着与更长的扫视反应时间和更多的不正确的反应，相比，青少年和成人。背外侧前额叶皮层在不同年龄组的参与情况相似，这表明在整个实验中，背外侧前额叶皮层在维持任务指令方面发挥着普遍作用。总的来说，这些发现表明，行为控制的发展改善得到了有效预设目标适当的大脑系统的改善的支持。(C)2014爱思唯尔公司All rights reserved.
The ability to prepare for an action improves the speed and accuracy of its performance. While many studies indicate that behavior performance continues to improve throughout childhood and adolescence, it remains unclear whether or how preparatory processes change with development. Here, we used a rapid event-related fMRI design in three age groups (8-12, 13-17, 18-25 years) who were instructed to execute either a prosaccade (look toward peripheral target) or an antisaccade (look away from target) task. We compared brain activity within the core fronto-parietal network involved in saccade control at two epochs of saccade generation: saccade preparation related to task instruction versus saccade execution related to target appearance. The inclusion of catch trials containing only task instruction and no target or saccade response allowed us to isolate saccade preparation from saccade execution. Five regions of interest were selected: the frontal, supplementary, parietal eye fields which are consistently recruited during saccade generation, and two regions involved in top down executive control: the dorsolateral prefrontal and anterior cingulate cortices. Our results showed strong evidence that developmental improvements in saccade performance were related to better saccade preparation rather than saccade execution. These developmental differences were mostly attributable to children who showed reduced fronto-parietal activity during prosaccade and antisaccade preparation, along with longer saccade reaction times and more incorrect responses, compared to adolescents and adults. The dorsolateral prefrontal cortex was engaged similarly across age groups, suggesting a general role in maintaining task instructions through the whole experiment. Overall, these findings suggest that developmental improvements in behavioral control are supported by improvements in effectively presetting goal-appropriate brain systems. (C) 2014 Elsevier Inc. All rights reserved.