During Running in Place, Grid Cells Integrate Elapsed Time and Distance Run
During Running in Place, Grid Cells Integrate Elapsed Time and Distance Run
复制标题
DOI：
10.1016/j.neuron.2015.09.031
复制
发表时间：
2015-11-04
期刊：
影响因子：
16.2
通讯作者：
Eichenbaum, Howard
中科院分区：
文献类型：
--
作者：
Kraus, Benjamin J.;Brandon, Mark P.;Eichenbaum, Howard
网格单元的空间尺度可以由自我生成的运动信息或由来自环境线索的外部感觉信息提供。为了确定网格细胞的活动是否反映了独立于外部信息的行进距离或流逝时间，我们记录了动物在跑步机上跑步时的网格细胞。网格细胞的活动只受到位置的微弱影响，但大多数网格细胞和其他神经元从相同的电极记录强烈信号的距离和时间的组合，与一些信号只有距离或时间。网格细胞比非网格细胞更敏锐地调整时间和距离。许多网格细胞表现出多个发射场在跑步机上运行，平行的周期性发射场观察到的开放领域，这表明一个共同的信息处理模式。这些观察结果表明，在没有外部动态线索的情况下，网格细胞整合自我生成的距离和时间信息来编码经验的表示。
The spatial scale of grid cells may be provided by self-generated motion information or by external sensory information from environmental cues. To determine whether grid cell activity reflects distance traveled or elapsed time independent of external information, we recorded grid cells as animals ran in place on a treadmill. Grid cell activity was only weakly influenced by location, but most grid cells and other neurons recorded from the same electrodes strongly signaled a combination of distance and time, with some signaling only distance or time. Grid cells were more sharply tuned to time and distance than non-grid cells. Many grid cells exhibited multiple firing fields during treadmill running, parallel to the periodic firing fields observed in open fields, suggesting a common mode of information processing. These observations indicate that, in the absence of external dynamic cues, grid cells integrate self-generated distance and time information to encode a representation of experience.