Antibodies to human T-cell leukemia virus membrane antigens (HTLV-MA) in hemophiliacs.
Antibodies to human T-cell leukemia virus membrane antigens (HTLV-MA) in hemophiliacs.
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血友病患者中的人类 T 细胞白血病病毒膜抗原 (HTLV-MA) 抗体。
DOI：
10.1126/science.6603659
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Evatt,BL
中科院分区：
文献类型：
--
作者：
Essex,M;McLane,MF;Lee,TH;Tachibana,N;Mullins,JI;Kreiss,J;Kasper,CK;Poon,MC;Landay,A;Stein,SF;Francis,DP;Cabradilla,C;Lawrence,DN;Evatt,BL
与同性恋者、海地人和静脉注射吸毒者一样，血友病患者感染获得性免疫缺陷综合症（艾滋病）的风险很高。一项早期研究显示，36% 的艾滋病患者体内含有与人类 T 细胞白血病病毒 (HTLV-MA) 相关的细胞膜抗原抗体，而匹配的无症状同性恋对照中只有 1.2% 含有这些抗体。在本实验中，检查了 172 名无症状血友病患者的血清样本中是否存在 HTLV-MA 抗体。在四个地理位置进行检查的血友病患者中，有 5% 至 19% 检测到此类抗体，但在实验室工作人员、正常献血者、血液透析献血者或患有慢性活动性肝炎的献血者中，只有 1% 或更少的人检测到此类抗体。
Along with homosexual men, Haitians, and intravenous drug abusers, hemophiliacs are at high risk of contracting acquired immunodeficiency syndrome (AIDS). An earlier study revealed that 36 percent of a group of the AIDS patients had antibodies to cell membrane antigens associated with the human T-cell leukemia virus (HTLV-MA), whereas only 1.2 percent of matched asymptomatic homosexual controls had these antibodies. In the present experiments, serum samples from 172 asymptomatic hemophiliacs were examined for the presence of antibodies to HTLV-MA. Such antibodies were detected in 5 to 19 percent of the hemophiliacs examined from four geographical locations, but in only 1 percent or less of laboratory workers, normal blood donors, donors on hemodialysis, or donors with chronic active hepatitis.