Serum and Cerebrospinal Fluid Antioxidant Activity and Lipid Peroxidation in Guillain-Barre Syndrome and Multiple Sclerosis Patients
Serum and Cerebrospinal Fluid Antioxidant Activity and Lipid Peroxidation in Guillain-Barre Syndrome and Multiple Sclerosis Patients
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DOI：
10.3109/00207451003695690
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发表时间：
2010-04-01
影响因子：
2.2
通讯作者：
Asadi, Farzad
中科院分区：
文献类型：
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作者：
Ghabaee, Mojdeh;Jabedari, Behnam;Asadi, Farzad
氧化应激通过活性氧水平和抗氧化参数的变化可引起各种神经系统疾病。本研究的目的是显示抗氧化活性（AOA）和丙二醛（MDA）水平在受影响的人与格林-巴利综合征（GBS）和多发性硬化症（MS）。本研究共纳入15例GBS患者、13例MS患者和15例年龄和性别匹配的对照。用荧光定量法测定脑脊液（CSF）和血清中MDA和AOA值。我们已经证明，与对照组（检测不到的水平）相比，GBS和MS患者CSF中的MDA值（0.32 +/- 0.073和0.22 +/- 0.06 μ mol/L）增加。此外，与对照组（1.7 +/- 0.46 μ mol/L）相比，GBS和MS患者（0.81 +/- 0.18和0.73 +/- 0.18 μ mol/L）的血清MDA水平均显著降低。与对照组（3.2 +/- 0.17 mmol/L）相比，GBS（1.7 +/- 0.21 mmol/L）和MS患者（2.6 +/- 0.62 mmol/L）的血清AOA均降低。然而，与对照组（0.71 +/- 0.19 mmol/L）相比，MS和GBS患者的CSF AOA值（1.47 +/- 0.19和1.42 +/- 0.26 mmol/L）显著增加。在MS和GBS患者中，CSF和血清中AOA和MDA水平之间的不平衡可以遵循。
Oxidative stress through the changes in the levels of reactive oxygen species and antioxidative parameters can cause various neurological disorders. The aim of the present study was to show antioxidant activity (AOA) and malondialdehyde (MDA) levels in affected people with Guillain-Barre syndrome (GBS) and multiple sclerosis (MS). A total of 15 GBS patients, 13 MS patients, and 15 age and sex matched controls were included in this study. MDA and AOA values were determined in both cerebrospinal fluid (CSF) and serum, spectrophotometrically. We have shown an increase in the values of MDA in the CSF of both GBS and MS patients (0.32 +/- 0.073 and 0.22 +/- 0.06 mu mol/L) compared to the control (undetectable levels). Furthermore, a significant decrease in the serum MDA levels was shown in both GBS and MS patients (0.81 +/- 0.18 and 0.73 +/- 0.18 mu mol/L) when compared to the control (1.7 +/- 0.46 mu mol/L). A decrease was shown for serum AOA in both GBS (1.7 +/- 0.21 mmol/L) and MS patients (2.6 +/- 0.62 mmol/L) when compared to the control (3.2 +/- 0.17 mmol/L). However, a significant increase in the values of CSF AOA was shown in both MS and GBS patients (1.47 +/- 0.19 and 1.42 +/- 0.26 mmol/L) compared to the control (0.71 +/- 0.19 mmol/L). An imbalance between the levels of AOA and MDA in both CSF and serum can be followed in both MS and GBS patients.