Online Databases and Circular RNAs
Online Databases and Circular RNAs
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DOI：
10.1007/978-981-13-1426-1_3
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发表时间：
2018-01-01
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通讯作者：
Aghaee-Bakhtiari, Seyed Hamid
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作者：
Aghaee-Bakhtiari, Seyed Hamid
circRNA是一类新的ncRNA，与其他ncRNA不同，它不是线性的，而是具有环状结构。这些有价值的ncRNA已在从植物到动物的广泛生物体以及所有细胞系和组织中检测到。通常，circRNA具有转录或转录后水平的基因表达调控、miRNA伙伴关系和剪接中介等功能。目前，circRNA在广泛的疾病集合中被粗略地标记，并且circRNA可以简单地在用于疾病检测和进展评估的液体样品中被识别。考虑到circRNA的这些特征，这些分子正在发展用于疾病治疗和诊断的原始生物标志物的完美集合。由于这些分子在医学和生物学的不同方面起着关键作用，因此circRNA被认为是当前ncRNA研究领域的关键和关键类别。为了简化对circRNA的不同特征的评估，已经建立了几个数据库，例如circBase、CircInteractome、CircNet、Circ2Traits、CircR2Disease、TCSD和CSCD。在本章中，我们对这些主要的circRNA数据库进行了概述，并介绍了每个数据库的主要功能。
circRNAs are a novel class of ncRNAs that unlike other ncRNAs are not linear and have a circular structure. These valuable ncRNAs have been detected in a wide range of organisms from plants to animals and in all cell lines and tissues. Commonly, circRNAs have several functions as gene expression regulation at transcriptional or posttranscriptional level, miRNA partnership, and splicing intercede. Currently, circRNAs are roughly remarked in a widespread collection of diseases, and circRNAs simply can be recognized in liquid samples for disease detection and progression assessment. Considering these features of circRNAs, these molecules are evolving the impeccable collection of original biomarkers for disease therapy and diagnosis. As the critical role of these molecules in different aspects medicine and biology, circRNAs are considered as key and critical class of ncRNA in the current ncRNA search field. To simplify the assessment of diverse features of circRNAs, several databases have been established such as circBase, CircInteractome, CircNet, Circ2Traits, CircR2Disease, TCSD, and CSCD. In this chapter, we have an overview on these main circRNA databases and introduce key features of each database.