PREDICTION OF LATE ASTHMATIC RESPONSES TO INHALED ALLERGEN
PREDICTION OF LATE ASTHMATIC RESPONSES TO INHALED ALLERGEN
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DOI：
10.1111/j.1365-2222.1984.tb02219.x
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发表时间：
1984-01-01
期刊：
影响因子：
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通讯作者：
HARGREAVE, FE
中科院分区：
文献类型：
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作者：
BOULET, LP;ROBERTS, RS;HARGREAVE, FE
对19例特应性哮喘患者的皮肤和支气管对变应原的反应进行了研究。变应原吸入试验在10名受试者中引起了孤立的早期哮喘反应（AR），在9名受试者中引起了双重哮喘反应（DAR）。豚草IgE RAST [放射性过敏原吸附试验]，与豚草抗原检测的患者的血清进行，产生了较高的值，但1例患者谁经历DAR比任何的患者。1例患者在豚草季节出现年度症状，豚草抗原和DAR吸入豚草提取物皮肤试验阳性，IgE RAST完全阴性，血清IgE浓度低。在皮肤点刺试验中也使用了用于吸入的每个个体的过敏原稀释液。在10 min时获得早期皮肤过敏反应（ECAR）平均风团直径，在6-8 h时获得晚期皮肤过敏反应（LCAR）平均直径。在ECAR和LCAR之间的关系方面，早期哮喘反应（ECAR）受试者与DAR受试者略有不同;在ECAR组中，在随后发生LCAR之前，需要明显更大的风团直径（P < 0.01），尽管存在一些重叠。一旦LCAR发展，则在LCAR的幅度上，在DAR组和DAR组之间没有差异。有一种趋势（不显著），即在ESTA组中需要更高的抗原浓度来引发LCAR。来自吸入抗原的分离的IgE的相关性包括以下：抗原的低阳性IgE RAST结果，6 mm的抗原，该抗原不会进行LCAR，并且在皮肤试验中需要高浓度的抗原以引发LCAR。DAR的相关性包括：抗原的高IgE RAST结果，抗原的ECAR风团直径< 5 mm，进而导致LCAR，以及皮肤试验中的低抗原浓度导致LCAR。观察到的迟发皮肤反应和迟发气道反应之间的对应关系是共同免疫学基础的证据。
Relationships between cutaneous and bronchial responses to allergen were examined in 19 atopic asthmatics. Allergen inhalation tests elicited an isolated early asthmatic response (EAR) in 10 subjects and a dual asthmatic response (DAR) in 9 subjects. Ragweed IgE RAST [radioallergosorbent test], performed with the sera of those patients tested with ragweed antigen, yielded higher values in all but 1 patient who experienced DAR than any of the patients with EAR. In 1 patient with annual symptoms in the ragweed season, positive skin tests with ragweed antigen and DAR to inhaled ragweed extracts, the IgE RAST was entirely negative and the serum IgE concentration was low. Dilutions of the allergen used in each individual for inhalation were also used in skin-prick tests. Early cutaneous allergic response (ECAR) mean wheal diameters were obtained at 10 min and late cutaneous allergic response (LCAR) mean diameters at 6-8 h. Early asthmatic response (EAR) subjects differed modestly from DAR subjects in the relationships between ECAR and LCAR; in the EAR group, a significantly larger wheal diameter (P < 0.01) was required before an LCAR ensued, although there was some overlap. Once LCAR developed, there was no difference between EAR and DAR groups in the magnitude of the LCAR. There was a trend (not significant) towards a requirement for a higher antigen concentration in the EAR group to elicit an LCAR. Correlates of an isolated EAR from inhaled antigen include the following: a low positive IgE RAST result with the antigen, ECAR .gtoreq. 6 mm with the antigen which does not proceed to a LCAR, and a high concentration of antigen is needed in skin tests to elicit an LCAR. Correlates of a DAR include the following: a high IgE RAST result with the antigen, an ECAR wheal diameter < 5 mm with the antigen proceeds to a LCAR, and a low antigen concentration in skin tests elicits an LCAR. The observed correspondence between the tendency to late skin and late airway responses is evidence of a common immunologic basis.