Development of a capsule endoscopy scoring index for small bowel mucosal inflammatory change
Development of a capsule endoscopy scoring index for small bowel mucosal inflammatory change
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DOI：
10.1111/j.1365-2036.2007.03556.x
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发表时间：
2008-01-15
影响因子：
7.6
通讯作者：
Lewis, B. S.
中科院分区：
文献类型：
--
作者：
Gralnev, I. M.;Defranchis, R.;Lewis, B. S.
研究背景胶囊内窥镜检查可识别小肠粘膜炎性改变。然而，目前还没有胶囊内窥镜检查结果的有效指标。目的建立胶囊内窥镜对小肠黏膜炎症变化的评分指标。首先，确定炎症变化的参数和描述符。其次，盲人读者前瞻性地对去识别视频中每个参数的存在或不存在进行评级，并对总体严重性的感知全球评估进行评级。第三，对各个参数和描述符按严重程度进行排序。第四，使用下降梯度法创建每个参数的值。前提是确保最后的数字分数反映了全球评估，并且全球评估与确定严重程度的排名一致。结果被汇编成三类：无或临床上不显著的变化，轻微的变化，以及中度或严重的变化。结果最终指标包括绒毛水肿、溃疡和狭窄3个参数。结论胶囊内窥镜评分为量化小肠炎性改变提供了一种通用语言。
Background Capsule endoscopy can identify small bowel mucosal inflammatory change. However, there has been no validated index for capsule endoscopy findings. This manuscript documents the development of such an index.Aim To develop a capsule endoscopy scoring index for small bowel mucosal inflammatory change.Methods The index was created in four separate steps. First, parameters and descriptors of inflammatory change were identified. Secondly, blinded readers prospectively graded the presence or absence of each parameter on de-identified videos and graded a perceived global assessment of overall severity. Thirdly, the individual parameters and descriptors were ranked in order of severity. Fourthly, values for each parameter were created using the descent gradient methodology. The premise was to assure that the final numerical score reflected the global assessment and that the global assessment agreed with the ranking of finding severity. Results were compiled for the three categories: no or clinically insignificant change, mild change, and moderate or severe change. Thresholds were determined.Results The final index includes three parameters: villous oedema, ulcer and stenosis. A score = 790 is moderate to severe.Conclusion This capsule endoscopy score provides a common language to quantify small bowel inflammatory changes.