mAKAP-a master scaffold for cardiac remodeling.
mAKAP-a master scaffold for cardiac remodeling.
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Makap-A主脚手架进行心脏改造。
DOI：
10.1097/fjc.0000000000000206
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发表时间：
2015-03
影响因子：
3
通讯作者：
Kapiloff MS
中科院分区：
文献类型：
--
作者：
Passariello CL;Li J;Dodge-Kafka K;Kapiloff MS
心脏重构受广泛的细胞内信号转导网络的调节。在这个网络中，许多信号通路中的每一个都对细胞适应的控制做出了独特的贡献。在过去的几年里，多分子信号复合体或信号小体对于细胞内信号的保真度和不同信号通路之间的串扰起着重要的作用。这些复合体整合上游信号并控制下游效应器。在心肌细胞中，mAKAPβ蛋白作为大型信号体的支架，对cAMP、钙、低氧和丝裂原激活的蛋白激酶信号做出反应。MAKAPβ信号体的主要功能是调节应激相关基因的表达，这些基因受转录因子NFATc、MEF2和HIF-1α以及控制病理性心肌肥厚的II型组蛋白去乙酰基酶的调控。
Cardiac remodeling is regulated by an extensive intracellular signal transduction network. Each of the many signaling pathways in this network contributes uniquely to the control of cellular adaptation. In the last few years, it has become apparent that multimolecular signaling complexes or ‘signalosomes’ are important for fidelity in intracellular signaling and for mediating crosstalk between the different signaling pathways. These complexes integrate upstream signals and control downstream effectors. In the cardiac myocyte, the protein mAKAPβ serves as a scaffold for a large signalosome that is responsive to cAMP, calcium, hypoxia, and mitogen-activated protein kinase signaling. The main function of mAKAPβ signalosomes is to modulate stress-related gene expression regulated by the transcription factors NFATc, MEF2 and HIF-1α and type II histone deacetylases that control pathological cardiac hypertrophy.