Targeting PDK1 for Chemosensitization of Cancer Cells.
Targeting PDK1 for Chemosensitization of Cancer Cells.
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DOI：
10.3390/cancers9100140
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发表时间：
2017-10-24
期刊：
影响因子：
5.2
通讯作者：
Falasca M
中科院分区：
文献类型：
--
作者：
Emmanouilidi A;Falasca M
尽管肿瘤学领域发展迅速，但癌症仍然是全球第二大死亡原因，预计未来几年新发病例数将增加一倍以上。化疗被广泛用于减缓或阻止肿瘤的发展，在适当的情况下与手术或放射治疗相结合，在许多情况下这可以改善疾病的症状。但不幸的是，化疗并不适用于所有患者，即使适用，在许多情况下，成功的初始治疗期后也会出现化疗耐药性。这是由多种原因引起的，从患者的遗传背景（先天抵抗）到肿瘤起始细胞的形成（获得性抵抗）。在这篇综述中，我们讨论了PDK1在不同类型恶性肿瘤化疗耐药发展中的潜在作用，以及促进化疗增敏的有效抑制剂的设计和应用。
Despite the rapid development in the field of oncology, cancer remains the second cause of mortality worldwide, with the number of new cases expected to more than double in the coming years. Chemotherapy is widely used to decelerate or stop tumour development in combination with surgery or radiation therapy when appropriate, and in many cases this improves the symptomatology of the disease. Unfortunately though, chemotherapy is not applicable to all patients and even when it is, there are many cases where a successful initial treatment period is followed by chemotherapeutic drug resistance. This is caused by a number of reasons, ranging from the genetic background of the patient (innate resistance) to the formation of tumour-initiating cells (acquired resistance). In this review, we discuss the potential role of PDK1 in the development of chemoresistance in different types of malignancy, and the design and application of potent inhibitors which can promote chemosensitization.
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影响因子：
17.1
作者：
Elkabets M;Vora S;Juric D;Morse N;Mino-Kenudson M;Muranen T;Tao J;Campos AB;Rodon J;Ibrahim YH;Serra V;Rodrik-Outmezguine V;Hazra S;Singh S;Kim P;Quadt C;Liu M;Huang A;Rosen N;Engelman JA;Scaltriti M;Baselga J
通讯作者：
Baselga J
影响因子：
50.3
作者：
Castel P;Ellis H;Bago R;Toska E;Razavi P;Carmona FJ;Kannan S;Verma CS;Dickler M;Chandarlapaty S;Brogi E;Alessi DR;Baselga J;Scaltriti M
通讯作者：
Scaltriti M
影响因子：
5.2
作者：
Di Blasio L;Gagliardi PA;Puliafito A;Primo L
通讯作者：
Primo L
影响因子：
5
作者：
Daniele, Simona;Sestito, Simona;Rapposelli, Simona
通讯作者：
Rapposelli, Simona
影响因子：
9.2
作者：
Alessi, DR;James, SR;Cohen, P
通讯作者：
Cohen, P