Human Papilloma Virus Identification in Breast Cancer Patients with Previous Cervical Neoplasia.
Human Papilloma Virus Identification in Breast Cancer Patients with Previous Cervical Neoplasia.
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DOI：
10.3389/fonc.2015.00298
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发表时间：
2015
影响因子：
4.7
通讯作者：
Whitaker NJ
中科院分区：
文献类型：
--
作者：
Lawson JS;Glenn WK;Salyakina D;Clay R;Delprado W;Cheerala B;Tran DD;Ngan CC;Miyauchi S;Karim M;Antonsson A;Whitaker NJ
与普通女性相比，患有人乳头瘤病毒(HPV)相关宫颈肿瘤的女性患乳腺癌的风险更高。这项研究的目的是(I)确定在同一患者中发生的宫颈肿瘤和随后的HPV阳性乳腺癌中的高危HPV，以及(Ii)确定这些HPV是否具有生物学活性。一系列聚合酶链式反应和免疫组织化学技术被用来对同一患者的宫颈癌前病变和随后的乳腺癌进行回顾性队列研究。在28名患者中，13名(46%)的宫颈和乳房标本中发现了相同的高危HPV类型。HPV18型最为常见。HPV E7蛋白的表达和HPV相关的空泡细胞的存在证明了HPV具有生物学活性。这些患者在有宫颈癌前期病史后被诊断为乳腺癌的平均年龄为51 岁，而所有患有乳腺癌的女性的平均年龄为60 岁(Difference = 0.001)。这些发现表明，高危HPV可能与宫颈肿瘤和随后的年轻乳腺癌有关。然而，这些关联并不常见，在乳腺癌中只占很小的比例。这些结果证实并扩展了先前两项类似研究的观察结果，并为年轻女性中严重浸润性乳腺癌发病率的增加提供了一种解释。
Women with human papilloma virus (HPV)-associated cervical neoplasia have a higher risk of developing breast cancer than the general female population. The purpose of this study was to (i) identify high-risk HPVs in cervical neoplasia and subsequent HPV positive breast cancers which developed in the same patients and (ii) determine if these HPVs were biologically active. A range of polymerase chain reaction and immunohistochemical techniques were used to conduct a retrospective cohort study of cervical precancers and subsequent breast cancers in the same patients. The same high-risk HPV types were identified in both the cervical and breast specimens in 13 (46%) of 28 patients. HPV type 18 was the most prevalent. HPVs appeared to be biologically active as demonstrated by the expression of HPV E7 proteins and the presence of HPV-associated koilocytes. The average age of these patients diagnosed with breast cancer following prior cervical precancer was 51 years, as compared to 60 years for all women with breast cancer (p for difference = 0.001). These findings indicate that high-risk HPVs can be associated with cervical neoplasia and subsequent young age breast cancer. However, these associations are unusual and are a very small proportion of breast cancers. These outcomes confirm and extend the observations of two similar previous studies and offer one explanation for the increased prevalence of serious invasive breast cancer among young women.