Effect of supplementation with dietary seal oil on selected cardiovascular risk factors and hemostatic variables in healthy male subjects
Effect of supplementation with dietary seal oil on selected cardiovascular risk factors and hemostatic variables in healthy male subjects
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DOI：
10.1016/s0049-3848(99)00106-1
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发表时间：
1999-11-01
影响因子：
7.5
通讯作者：
Holub, BJ
中科院分区：
文献类型：
--
作者：
Conquer, JA;Cheryk, LA;Holub, BJ
因纽特人每天平均食用海豹油约8-9克，但关于食用海豹油对心血管疾病风险因素影响的信息很少。在这项研究中，19名健康、胆固醇正常的受试者每天食用20 g含有二十碳五烯酸（EPA; 20，5 n-3）、二十二碳六烯酸（DHA; 22：6 n-3）和二十二碳五烯酸（DPA：22：5 n-3）的胶囊化海豹油或20 g植物油（对照），持续42天。测定了选定的心血管和血栓形成危险因素的水平以及血清磷脂和非酯化脂肪酸（NEFA）的脂肪酸谱，在补充海豹油的组中，血清磷脂和NEFA中的EPA水平分别增加了4.3倍和2.7倍，DHA水平分别增加了1.5倍和2.1倍，DPA水平分别增加了0.5倍和0.7倍，分别花生四烯酸（AA）水平下降了26%，血清磷脂和血清NEFA。血清磷脂中n-6与n-3脂肪酸的比值从7.2显著降低至2.1，NEFA中EPA/AA的比值显著增加。摄入海豹油使凝血抑制剂蛋白C值升高7%，使血浆纤维蛋白原降低18%。在两组中均未观察到其他止血变量（包括因子VII、VIII、IX和X以及抗凝血酶的血浆活性）或血管性血友病因子、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯、葡萄糖、Apo A-1或脂蛋白（a）浓度的变化。其他心血管疾病的危险因素，包括红细胞压积、白色血细胞计数、血浆粘度、收缩压和舒张压、心率和ADP或胶原刺激后的血小板聚集没有变化。我们的研究结果表明，在健康的、胆固醇血症正常的受试者中补充海豹油降低了n-6/n-3比率，增加了血清磷脂和NEFA中的EPA、DHA和DPA以及EPA/AA和DHA/AA的比率，同时对纤维蛋白原和蛋白C水平表现出适度的有益作用。(C)1999爱思唯尔科技有限公司。保留所有权利。
The average daily consumption of seal oil by the Inuit people is approximately 8-9 g, yet there is very little information on the effect of seal oil consumption on cardiovascular disease risk factors. In this study, 19 healthy, normocholesterolemic subjects consumed 20 g of encapsulated seal oil containing eicosapentaenoic acid (EPA; 20,5n-3), docosahexaenoic acid (DHA; 22:6n-3), and docosapentaenoic acid (DPA: 22:5n-3) or 20 g of vegetable: oil (control) per day for 42 days. Levels of selected cardiovascular and thrombotic risk factors as well as fatty acid profiles of serum phospholipid and nonesterified fatty acid (NEFA) were determined, EPA levels in serum phospholipid and NEFA increased by 4.3- and 2.7-fold, respectively, in the seal oil supplemented group, DHA levels rose 1.5- and 2.1-fold, respectively, and DPA levels rose 0.5- and 0.7-fold, respectively. Arachidonic acid (AA) levels dropped by 26% in both serum phospholipid and serum NEFA. There was a significant decrease in the ratio of n-6 to n-3 fatty acids in serum phospholipid from 7.2 to 2.1 and a significant increase in the ratio of EPA/AA in NEFA. Ingestion of seal oil raised the coagulant inhibitor, protein C, values by 7% and decreased plasma fibrinogen by 18%. No alterations in other hemostatic variables, including plasma activity of Factors VII, VIII, IX, and X and antithrombin, or in the concentrations of von Willebrand Factor, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, glucose, Apo A-1, or lipoprotein(a) were observed in either group. Other risk factors for cardiovascular disease, including hematocrit, white blood cell count, plasma viscosity, systolic and diastolic blood pressures, heart rate, and platelet aggregation after stimulation with ADP or collagen did not change. Our results indicate that seal oil supplementation in healthy, normocholesterolemic subjects decreased the n-6/n-3 ratio and increased EPA, DHA, and DPA and the ratio of EPA/AA and DHA/AA in the serum phospholipid and NEFA while exhibiting a modest beneficial effect on fibrinogen and protein C levels. (C) 1999 Elsevier Science Ltd. All rights reserved.