Increased expression of the CD45RO (memory) antigen on T cells in HIV-infected children.
Increased expression of the CD45RO (memory) antigen on T cells in HIV-infected children.
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HIV 感染儿童 T 细胞上 CD45RO（记忆）抗原的表达增加。
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
A. Graham Bird
中科院分区：
文献类型：
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作者：
Karin S. Froebel;Kathleen V. Doherty;J. Whitelaw;Rosemary A. Hague;Jacqueline Y. Mok;A. Graham Bird
用UCHL1抗体检测了HIV感染妇女所生子女的辅助细胞和细胞抑制细胞表面CD45RO记忆细胞抗原的表达。9例感染患儿的CD45RO+CD8淋巴细胞数均显著高于未感染患儿和对照组。CD45RO在CD4淋巴细胞上的表达是可变的；绝对数没有增加，尽管在9个感染儿童中有4个增加了百分比。除2例(CD45RO+CD8细胞相对较少)外，其余患儿临床表现良好，提示CD45RO+CD8细胞增多可能是抗HIV的功能性主动免疫反应。
Expression of the CD45RO putative memory cell antigen on CD4 (helper) and CD8 (cytotoxic/suppressor) lymphocytes of children born to HIV-infected women was investigated using the UCHL1 antibody. Significantly raised numbers of CD45RO+ CD8 lymphocytes were found in all nine of the infected children compared with uninfected and control children. Expression of CD45RO on CD4 lymphocytes was variable; absolute numbers were not increased, although the percentage was increased in four out of nine infected children. All the infected children except two (who had comparatively low numbers of CD45RO+ CD8 cells) were clinically well, which suggests that an increase in CD45RO+ CD8 cells may be indicative of a functionally active immune response against HIV.