Looking beyond prevention of parent to child transmission: Impact of maternal factors on growth of HIV-exposed uninfected infant.
Looking beyond prevention of parent to child transmission: Impact of maternal factors on growth of HIV-exposed uninfected infant.
复制标题
除了预防父母到传播父母的外观：母亲因素对艾滋病毒暴露于未感染的婴儿的生长的影响。
DOI：
10.4103/0253-7184.142404
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发表时间：
2014-07
影响因子：
0.4
通讯作者：
Shah VB
中科院分区：
文献类型：
--
作者：
Sangeeta T;Anjali M;Silky M;Kosambiya JK;Shah VB
Compared to HIV-infected children, relatively little has been described regarding the health status, particularly growth of HIV-exposed but uninfected children in resource-limited settings. This is particularly relevant with widespread implementation of the prevention of parent to child transmission program. At a tertiary care health institute in India, a cohort of 44 HIV-exposed but uninfected children were followed through 6 months of age. The anthropometric parameters weight, length, and head circumference were investigated at birth, 3 weeks, 6 weeks, 3 months, and 6 months point of time. The information on maternal characteristics such as HIV clinical staging, CD4 count, and maternal weight were recorded. The linear regression analysis was applied to estimate the influence of maternal characteristics on infant anthropometric parameters. Anthropometric parameters (weight, length and head circumference) were significantly reduced in uninfected new-borns of mothers in HIV Clinical stage III and IV and weight <50 kg compared to mothers in HIV Clinical stage I and II and weight >50 kg. Analysis conducted to find the effect of maternal immunosuppression on infant growth reveals a significant difference at CD4 300 cells/mm3 and not at established cut-off of CD4 350 cells/mm3. This trend of difference continued at 6 weeks, 3 months, and 6 months. The multiple linear regression analysis model demonstrated maternal HIV clinical stage and weight as predictors for birth weight and length, respectively. Advanced HIV disease in the mother is associated with poor infant growth in HIV-exposed, but uninfected children at a critical growth phase in life. These results underscore the importance, especially in resource-constrained settings, of early HIV diagnosis and interventions to halt disease progression in all pregnant women.
