A tale of two STAT6 knock out mice in the induction of experimental autoimmune encephalomyelitis.
A tale of two STAT6 knock out mice in the induction of experimental autoimmune encephalomyelitis.
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DOI：
10.1016/j.jneuroim.2008.11.003
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发表时间：
2009-01-03
影响因子：
3.3
通讯作者：
Bynoe, Margaret S.
中科院分区：
文献类型：
--
作者：
Wang, Yongmei;Evans, J. T.;Rodriguez, Frederick;Fields, Patrick;Mueller, Cynthia;Chitnis, Tanuja;Khoury, Samia J.;Bynoe, Margaret S.
T helper 2 (Th2) cytokines are known to be important in protection against experimental autoimmune encephalomyelitis (EAE). To investigate the role of the signal transducer and activator of transcription factor 6 (STAT6) in EAE we used mice with two different targeted disruptions of the STAT6 gene. In this report, we show that mice with targeted deletion of the first coding exon of the SH2 domain of STAT6 induce Th2 cell differentiation and are resistant to EAE induction. By contrast, STAT6−/− mice generated by deletion of amino acids 505 to 584 encoding the SH2 domain of STAT6 are defective in Th2 cell differentiation and develop very severe EAE. These results suggest that an altered STAT6 gene can be more efficient than wild type STAT6 in regulating the autoimmune response in EAE.
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影响因子：
64.5
作者：
Ivanov, Ivaylo I.;McKenzie, Brent S.;Littman, Dan R.
通讯作者：
Littman, Dan R.
影响因子：
32.4
作者：
Bynoe, MS;Evans, JT;Janeway, CA
通讯作者：
Janeway, CA
影响因子：
3.3
作者：
ISSAZADEH, S;LJUNGDAHL, A;OLSSON, T
通讯作者：
OLSSON, T
DOI：
10.1084/jem.185.5.901
发表时间：
1997-03-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Falcone M;Bloom BR
通讯作者：
Bloom BR
DOI：
10.1073/pnas.92.2.354
发表时间：
1995-01-17
影响因子：
11.1
作者：
HARDARDOTTIR, F;BARON, JL;JANEWAY, CA
通讯作者：
JANEWAY, CA