THE PARTICIPATION OF SHIVERING AND NON-SHIVERING THERMOGENESIS IN WARM AND COLD-ACCLIMATED RATS
THE PARTICIPATION OF SHIVERING AND NON-SHIVERING THERMOGENESIS IN WARM AND COLD-ACCLIMATED RATS
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DOI：
10.1016/0300-9629(82)90189-x
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发表时间：
1982-01-01
影响因子：
2.3
通讯作者：
GRIGGIO, MA
中科院分区：
文献类型：
--
作者：
GRIGGIO, MA
发抖和非发抖生热都是增加大鼠氧气消耗的方式。冷习服后非颤抖产热的参与已得到很好的证实，但几乎没有证据表明每种产热在习服和非习服大鼠中的相对重要性。测量了热习服和冷习服大鼠的氧耗量和直肠温度，这两种动物都暴露在寒冷(10度。C)和温暖(30度)。C)环境。美非那辛(10 mg/100g体重)阻断寒战，普奈洛尔(0.5 mg/100g体重)阻断非颤抖发热。对照组注射生理盐水(0.5ml/100g体重)。寒战不能有效地维持恒定的直肠温度，而非寒战生热作用不会增加热习服冷暴露大鼠的耗氧量。
Both shivering and nonshivering thermogenesis are ways of increasing O2 consumption in the rat. The participation of nonshivering thermogenesis afer cold acclimation is well established, but there is little evidence of the relative importance of each kind of thermogenesis in acclimated and nonacclimated rats. O2 consumption and rectal temperature were measured in warm and cold-acclimated rats, exposed both to cold (10.degree. C) and warm (30.degree. C) environments. Shivering was blocked by mephenesin (10 mg/100 g body wt) and nonshivering thermogenesis was blocked by propranolol (0.5 mg/100 g body wt). Control animals were injected with saline (0.5 ml/100 g body wt). Shivering is not effective in maintaining a constant rectal temperature and nonshivering thermogenesis does not contribute to the increase in O2 consumption of warm-acclimated rats exposed to cold.