Leishmania susceptibility puzzle gets another twist.
Leishmania susceptibility puzzle gets another twist.
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利什曼原虫易感性之谜又出现了新的转折。
DOI：
10.1126/science.271.5251.912
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发表时间：
1996
期刊：
影响因子：
56.9
通讯作者：
J. Marx
中科院分区：
文献类型：
--
作者：
J. Marx
一种名为 BALB/c 的小鼠品系无法抵抗一种名为大利什曼原虫的寄生原生动物的感染。了解动物为何无法对寄生虫发起细胞介导的免疫攻击，可能有助于免疫学家了解为什么人类对利什曼原虫的易感性也存在差异，据信利什曼原虫在全世界范围内困扰着 1200 万人。研究人员一直在追踪一个有希望的线索：动物似乎会产生由细胞因子白细胞介素 4 (IL-4) 介导的不适当的抗体反应。现在，本期的两篇论文（[第 984 页][1] 和 [987][2]）对这个想法提出了质疑。他们表明 IL-4 根本不参与其中，而是动物的 T 细胞无法对另一种细胞因子 IL-12 做出反应，而 IL-12 有助于触发细胞介导的免疫。尽管如此，其他免疫学家注意到大量相互矛盾的数据，尚未准备好否认 IL-4 是动物利什曼原虫易感性的原因。
[1]：/lookup/volpage/271/pp。第984章
[2]：/lookup/doi/10.1126/science.271.5251.987
A strain of mice called BALB/c can't fight off infection by a parasitic protozoan called Leishmania major . Understanding why the animals fail to mount a cell-mediated immune attack on the parasite might help immunologists understand why human beings also vary in their susceptibility to Leishmania , which is believed to afflict 12 million people worldwide. Researchers have been following a promising lead: The animals appear to make an inappropriate antibody response, mediated by the cytokine interleukin-4 (IL-4). Now two papers in this issue ( [pp. 984][1] and [987][2]) put that idea in doubt. They indicate that IL-4 is not involved at all, but rather that the animals' T cells are unable to respond to another cytokine, interleukin-12, that helps trigger cell-mediated immunity. Still, other immunologists, noting the large amount of contradictory data, are not yet ready to dismiss IL-4 as a cause of the animals' Leishmania susceptibility.
[1]: /lookup/volpage/271/pp. 984
[2]: /lookup/doi/10.1126/science.271.5251.987