A STEREOTACTIC METHOD OF ANATOMICAL LOCALIZATION FOR POSITRON EMISSION TOMOGRAPHY
A STEREOTACTIC METHOD OF ANATOMICAL LOCALIZATION FOR POSITRON EMISSION TOMOGRAPHY
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DOI：
10.1097/00004728-198501000-00025
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发表时间：
1985-01-01
影响因子：
1.3
通讯作者：
RAICHLE, ME
中科院分区：
文献类型：
--
作者：
FOX, PT;PERLMUTTER, JS;RAICHLE, ME
用于生理图像内的解剖定位的现有方法不足以用于解剖和生理之间的精确区域相关性。开发了一种用于通过将断层摄影位置坐标变换成人脑的立体定向图谱内的坐标来确定正电子发射断层摄影（PET）图像内的任何感兴趣区域的位置的方法。这种方法的具体解剖假设，确定和验证组内的正常受试者的侧颅骨X线片和核磁共振质子图像的测量手段。当该技术应用于正常受试者组时，通过确定2个生理定义的PET区域的解剖位置：海绵窦和视觉反应皮层，证明了高度的准确性和可重复性。该方法实现简单，客观性强。与结构断层摄影术一起使用的定位程序的推广是容易完成的。
Extant methods for anatomical localization within a physiological image are inadequate for precise regional correlations between anatomy and physiology. A method was developed for determining the location of any region of interest within a positron emission tomographic (PET) image by transformation of the tomographic location coordinates into coordinates within a stereotactic atlas of the human brain. The specific anatomical assumptions of this approach were identified and validated within groups of normal subjects by means of measurements made from lateral skull radiographs and NMR proton images. A high degree of accuracy and reproductibility was demonstrated when this technique was applied to groups of normal subjects by determining the anatomical location of 2 physiologically defined PET areas: the cavernous sinus and visually responsive cortex. This method is simple to implement and highly objective. Generalization of the localization procedure for use with structural tomography is readily accomplished.