Effects of Valsalva Maneuver on Anterior Chamber Parameters and Choroidal Thickness in Healthy Chinese: An AS-OCT and SS-OCT Study
Effects of Valsalva Maneuver on Anterior Chamber Parameters and Choroidal Thickness in Healthy Chinese: An AS-OCT and SS-OCT Study
复制标题
Valsalva 动作对健康中国人前房参数和脉络膜厚度的影响：AS-OCT 和 SS-OCT 研究
DOI：
10.1167/iovs.15-18449
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发表时间：
2016-10-01
影响因子：
4.4
通讯作者：
Zhang, Xiulan
中科院分区：
文献类型：
--
作者：
Li, Xingyi;Wang, Wei;Zhang, Xiulan
目的。本研究同时评估了Valsalva手法（VM）对中国健康人群眼前、眼后生物特征参数的影响。这项前瞻性的横断面研究使用前段光学相干断层扫描（AS-OCT）和扫源光学相干断层扫描（SS-OCT）来测量虚拟机之前和过程中的前眼和后眼生物特征参数。63名志愿者（126只眼睛，17名男性，46名女性）被招募。分别记录眼内压、血压（BP）和屈光不正。平均IOP升高有统计学意义（13.86 ~ 14.25 mm Hg, P = 0.005），但视网膜各层及脉络膜厚度（CT）无明显变化。前房参数较基线急剧下降，角度开口距离（AOD500从0.35 ~ 0.31 mm, P < 0.001）、AOD750（从0.44 ~ 0.39 mm, P = 0.007）、小梁-虹膜间隙面积（TISA500从0.14 ~ 0.13 mm, P = 0.027）、TISA750（从0.25 ~ 0.23 mm, P = 0.007）、前房容积（ACV从143.09 ~ 139.84 mm, P = 0.036）减小。回归分析显示Delta IOP与基线IOP （beta = 0.26 [0.15, 0.37], P < 0.001）和Delta ACW （beta = -3.24 [-5.65, -0.83], P = 0.008）之间存在相关性。这项研究是第一个同时评估虚拟机对前眼和后眼生物特征参数影响的研究。VM引起健康受试者眼压明显升高和角度变窄。但对黄斑区的CT未见改变。VM中IOP升高与脉络膜扩张的关系有待进一步研究。
PURPOSE. This study concurrently evaluated the effects of the Valsalva maneuver (VM) on the anterior and posterior ocular biometric parameters in a healthy Chinese cohort.METHODS. This prospective, cross-sectional study used anterior segment optical coherence tomography (AS-OCT) and swept-source optical coherence tomography (SS-OCT) to measure the anterior and posterior ocular biometric parameters before and during the VM. Sixty-three volunteers (126 eyes; 17 males and 46 females) were enrolled. The IOP, blood pressure (BP), and refractive error were recorded before and during a VM.RESULTS. The mean IOP showed a statistically significant increase (from 13.86-14.25 mm Hg, P = 0.005), but the different layers of the retina and the choroidal thickness (CT) showed no significant changes. The anterior chamber parameters decreased sharply from the baseline, with a smaller angle opening distance (AOD500; from 0.35-0.31 mm, P < 0.001), AOD750 (from 0.44-0.39 mm, P = 0.007), trabecular-iris space area (TISA500; from 0.14-0.13 mm, P = 0.027), TISA750 (from 0.25-0.23 mm, P = 0.007), and anterior chamber volume (ACV; from 143.09-139.84 mm(3) P = 0.036). Regression analyses revealed an association between Delta IOP and the baseline IOP (beta = 0.26 [0.15, 0.37], P < 0.001) and Delta ACW (beta = -3.24 [-5.65, -0.83], P = 0.008).CONCLUSIONS. This study is the first to provide simultaneous evaluation of the effects of the VM on anterior and posterior ocular biometric parameters. The VM caused a significant IOP increase and narrowing of the angles in healthy subjects. However, it did not change the CT in the macular region. The relationship between IOP elevation and choroidal expansion during the VM needs further investigation.