Studies of the Mortality of Atomic Bomb Survivors, Report 14, 1950-2003: An Overview of Cancer and Noncancer Diseases
Studies of the Mortality of Atomic Bomb Survivors, Report 14, 1950-2003: An Overview of Cancer and Noncancer Diseases
复制标题
DOI：
10.1667/rr2629.1
复制
发表时间：
2012-03-01
影响因子：
3.4
通讯作者：
Kodama, Kazunori
中科院分区：
文献类型：
--
作者：
Ozasa, Kotaro;Shimizu, Yukiko;Kodama, Kazunori
Ozasa，K.，Shimizu，Y.，Suyama，A.，Kasagi，F.，Soda，M.，Grant，E.J.，Sakata，R.，Sugiyama，H.和Kodara，K.原子弹幸存者的死亡率研究，报告14,1950-2003：癌症和非癌症疾病概述。辐射。这是关于原子弹幸存者寿命研究(LSS)队列死亡率的一系列定期一般性报告中的第14份报告，随后是辐射影响研究基金会调查原子弹辐射对后期健康影响的报告。在1950-2003年期间，86,611名LSS队列成员中有58%的人死亡，这些成员的剂量估计为DS02。自上次报告以来的6年的额外跟踪在辐射暴露后的较长时间内提供了更多的信息(癌症死亡增加了17%)，特别是在10岁以下暴露的人(增加了58%的死亡)。使用泊松回归方法调查辐射相关风险的大小、剂量反应的形状以及性别、暴露年龄和达到的年龄对影响的影响。所有死因的风险与辐射剂量呈正相关。重要的是，对于实体癌症来说，相加辐射风险(即每104人年每射线超额癌症病例)在一生中继续增加，呈线性剂量-反应关系。基于线性模型，所有70岁的实体癌在30岁时暴露后的性别平均超额相对危险度为0.42[95%可信区间：0.32，0.53]。年龄每减少十年，风险增加约29%(95%可信区间：17%，41%)。对于所有实体癌，估计的具有显著误差的最低剂量范围是0到0.20Gy，正式的剂量-阈值分析表明没有阈值；即，零剂量是阈值的最佳估计。大多数主要部位的癌症死亡风险显著增加，包括胃、肺、肝、结肠、乳房、胆囊、食道、膀胱和卵巢，而直肠、胰腺、子宫、前列腺和肾实质的风险没有显著增加。观察到包括循环系统、呼吸系统和消化系统在内的非肿瘤性疾病的风险增加，但这些是否是因果关系还需要进一步调查。没有证据表明辐射对传染病或外部死亡原因有影响。(C)2012年，由辐射研究学会提供
Ozasa, K., Shimizu, Y., Suyama, A., Kasagi, F., Soda, M., Grant, E. J., Sakata, R., Sugiyama, H. and Kodama, K. Studies of the Mortality of Atomic Bomb Survivors, Report 14, 1950-2003: An Overview of Cancer and Noncancer Diseases. Radiat. Res. 177, 229-243 (2012).This is the 14th report in a series of periodic general reports on mortality in the Life Span Study (LSS) cohort of atomic bomb survivors followed by the Radiation Effects Research Foundation to investigate the late health effects of the radiation from the atomic bombs. During the period 1950-2003, 58% of the 86,611 LSS cohort members with DS02 dose estimates have died. The 6 years of additional follow-up since the previous report provide substantially more information at longer periods after radiation exposure (17% more cancer deaths), especially among those under age 10 at exposure (58% more deaths). Poisson regression methods were used to investigate the magnitude of the radiation-associated risks, the shape of the dose response, and effect modification by gender, age at exposure, and attained age. The risk of all causes of death was positively associated with radiation dose. Importantly, for solid cancers the additive radiation risk (i.e., excess cancer cases per 104 person-years per Gy) continues to increase throughout life with a linear dose-response relationship. The sex-averaged excess relative risk per Gy was 0.42 [95% confidence interval (CI): 0.32, 0.53] for all solid cancer at age 70 years after exposure at age 30 based on a linear model. The risk increased by about 29% per decade decrease in age at exposure (95% CI: 17%, 41%). The estimated lowest dose range with a significant ERR for all solid cancer was 0 to 0.20 Gy, and a formal dose-threshold analysis indicated no threshold; i.e., zero dose was the best estimate of the threshold. The risk of cancer mortality increased significantly for most major sites, including stomach, lung, liver, colon, breast, gallbladder, esophagus, bladder and ovary, whereas rectum, pancreas, uterus, prostate and kidney parenchyma did not have significantly increased risks. An increased risk of non-neoplastic diseases including the circulatory, respiratory and digestive systems was observed, but whether these are causal relationships requires further investigation. There was no evidence of a radiation effect for infectious or external causes of death. (C) 2012 by Radiation Research Society